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Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow

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  • SPECIAL TOPIC · Organic Photochemistry
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Abstract

Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, 72701, USA

    Jiang Wang, Theresa H. Nguyen & Nan Zheng

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  1. Jiang Wang
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  2. Theresa H. Nguyen
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  3. Nan Zheng
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Correspondence to Nan Zheng.

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Wang, J., Nguyen, T.H. & Zheng, N. Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow. Sci. China Chem. 59, 180–183 (2016). https://doi.org/10.1007/s11426-015-5547-y

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  • DOI: https://doi.org/10.1007/s11426-015-5547-y

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