Abstract
p-Quinols are ubiquitous structural motifs of various natural products and pharmaceutical compounds, and versatile building blocks in synthetic chemistry. The reported methods for the synthesis of p-quinol require stoichiometric amounts of oxidants. Molecular oxygen is considered as an ideal oxidant due to its natural, inexpensive, and environmentally friendly characteristics. During the ongoing research of C-H bond hydroxylation, we found that multi-alkyl phenols could react with molecular oxygen under mild conditions. Herein, we describe an efficient oxidative de-aromatization of multi-alkyl phenols to p-quinols. 1 atm of molecular oxygen was used as the oxidant. Many multi-alkyl phenols could react smoothly at room temperature. Isotopic labeling experiment was also performed, and the result proved that the oxygen atom in the produced hydroxyl group is from molecular oxygen.
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Wang X, Porco JA. Synthesis of the tetracyclic core of the tetrapetalones through transannular oxidative [4+3] cyclization. Angew Chem Int Ed, 2005, 44: 3067–3071
Zilbeyaz K, Sahin E, Kilic H. Synthesis of enantiomerically pure analogues of the meta-substituted aniline antibiotics. Tetrahedron: Asymmetry, 2007, 18: 791–796
Patil AD, Freyer AJ, Killmer L, Offen P, Carte B, Jurewiz AJ, Johnson RK. Frondosins, five new sesquiterpene hydroquinone derivatives with novel skeletons from the sponge dysidea frondosa: inhibitors of interleukin-8 receptors. Tetrahedron, 1997, 53: 5047–5060
Ata A, Kerr RG, Moya CE, Jacobs RS. Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae. Tetrahedron, 2003, 59: 4215–4222
García-García C, Redondo MC, Ribagorda M, Carreño MC. Reactions of p-quinols with aldehydes and imines: stereoselective access to polyheterobicyclic and tricyclic systems. Eur J Org Chem, 2014, 33: 7377–7388
Baldwin JE, Adlington RM, Sham VWW, Marquez R, Bulger PG. Biomimetic synthesis of (±)-aculeatin D. Tetrahedron, 2005, 61: 2353–2363
Redondo MC, Ribagorda M, Carreño MC. Exploring Morita-Baylis-Hillman reactions of p-quinols. Org Lett, 2010, 12: 568–571
Barradas S, Carreño MC, González-López M, Latorre A, Urbano A. Direct stereocontrolled synthesis of polyoxygenated hydrobenzofurans and hydrobenzopyrans from p-peroxy quinols. Org Lett, 2007, 9: 5019–5022
Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew EH, Stevens MFG, Westwell AD. Quinols as novel therapeutic agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. J Med Chem, 2005, 48: 639–644
McCarroll AJ, Bradshaw TD, Westwell AD, Mattews CS, Stevens MFG. Quinols as novel therapeutic agents. 7. Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by sonogashira reactions. J Med Chem, 2007, 50: 1707–1710
Capes A, Patterson S, Wyllie S, Hallyburton I, Collie IT, McCarroll AJ, Stevens MFG, Frearson JA, Wyatt PG, Fairlamb AH, Gilbert IH. Quinol derivatives as potential trypanocidal agents. Bioorg Med Chem, 2012, 20: 1607–1615
Wells G, Berry JM, Bradshaw TD, Burger AM, Seaton A, Wang B, Westwell AD, Stevens MFG. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. J Med Chem, 2003, 46: 532–541
Magdziak D, Meek SJ, Pettus TRR. Cyclohexadienone ketals and quinols: four building blocks potentially useful for enantioselective synthesis. Chem Rev, 2004, 104: 1383–1429
Quideau S, Pouységu L, Deffieux D. Oxidative dearomatization of phenols: why, how and what for? Synlett, 2008, 4: 467–495
Pelter A, Elgendy SMA. Phenolic oxidations with phenyliodonium diacetate. J Chem Soc, Perkin Trans 1, 1993: 1891–1896
Pitsinos EN, Moutsos VI, Vageli O. Synthesis of enantiopure (S)-7-hydroxy-3-amino-3,4-dihydro-2H-1-benzopyran en route to (+)-scyphostatin. Tetrahedron Lett, 2007, 48: 1523–1526
Moriarty RM, Prakash O. Oxidation of phenolic compounds with organohypervalent iodine reagents. Org React, 2001, 57: 327–415
Parra A, Reboredo S. Chiral hypervalent iodine reagents: synthesis and reactivity. Chem Eur J, 2013, 19: 17244–17260
Zheng Z, Zhang-negrerie D, Du Y, Zhao K. The applications of hypervalent iodine(III) reagents in the constructions of heterocyclic compounds through oxidative coupling reactions. Sci China Chem, 2014, 57: 189–214
McKillop A, Perry DH, Edwards M. Antus S, Farkas L, Nogradi M, Taylor EC. Thallium in organic synthesis. XLII. Direct oxidation of 4-substituted phenols to 4,4-disubstituted cyclohexa-2,5-dienones using thallium(III) nitrate. J Org Chem, 1976, 41: 282–287
Milić DR, Gašić MJ, Muster W, Csanádi JJ, Šolaja BA. The synthesis and biological evaluation of a-ring substituted steroidal p-quinones. Tetrahedron, 1997, 53: 14073–14084
Šolaja BA, Milić DR, Gašić MJ. A novel m-CPBA oxidation: p-quinols and epoxyquinols from phenols. Tetrahedron Lett, 1996, 37: 3765–3768
Omura K. p-Quinols and p-quinol ethers from 2,4,6-trialkylphenols. Synthesis, 2010, 2: 208–210
Becker HD, Gustafsson K. Oxidation of sterically hindered phenols by periodic acid. J Org Chem 1979, 44: 428–432
Sels BF, De Vos DE, Jacobs PA. Bromide-assisted oxidation of substituted phenols with hydrogen peroxide to the corresponding p-quinol and p-quinol ethers over WO4 2−-exchanged layered double hydroxides. Angew Chem Int Ed, 2005, 44: 310–313
Nardello V, Bogaert S, Alsters PL, Aubry JM. Singlet oxygen generation from H2O2/MoO4 2−: peroxidation of hydrophobic substrates in pure organic solvents. Tetrahedron Lett, 2002, 43: 8731–8734
Carreño MC, González-López M, Urbano A. Oxidative de-aromatization of para-alkyl phenols into para-peroxyquinols and para-quinols mediated by oxone as a source of singlet oxygen. Angew Chem Int Ed, 2006, 45: 2737–2741
Yakura T, Omoto M, Yamauchi Y, Tian Y, Ozono A. Hypervalent iodine oxidation of phenol derivatives using a catalytic amount of 4-iodophenoxyacetic acid and oxone as a co-oxidant. Tetrahedron, 2010, 66: 5833–5840
Yakura T, Omoto M. Efficient synthesis of p-quinols using catalytic hypervalent iodine oxidation of 4-arylphenols with 4-iodophenoxy-acetic acid and oxone. Chem Pharm Bull, 2009, 57: 643–645
Crandall JK, Zucco M, Kirsch RS, Coppert DM. The formation of orthoquinones in the dimethyldioxirane oxidation of phenols. Tetrahedron Lett, 1991, 32: 5441–5444
Loginova IV, Chukicheva IY, Kuchin AV. Oxidation of substituted phenols with chlorine dioxide. Russ J Org Chem, 2011, 47: 1501–1503
Prokai-Tatrai K, Rivera-Portalatin NM, Rauniyar N, Prokai L. A facile microwave-assisted synthesis of p-quinols by lead(IV) acetate oxidation. Lett Org Chem, 2007, 4: 265–267
Adam W, Kiliç H, Saha-Möller CR. An efficient regioselective and diastereoselective synthesis of the epoxy-quinol functionality as building block for the manumycin antibiotics by the sequence of photooxygenation, reduction and Weitz-Scheffer epoxidation. Synlett, 2002, 3: 510–512
Bakshi R, Mathur P. Organo-peroxyl compounds via catalytic oxidation of a hindered phenol and aniline utilizing new manganese(II) bis benzimidazole diamide based complexes. Inorg Chim Aata, 2010, 363: 3477–3488
DeRosa MC, Crutchley RJ. Photosensitized singlet oxygen and its applications. Coord Chem Rev, 2002, 233–234: 351–371
Shi Z, Zhang C, Tang C, Jiao N. Recent advances in transition-metal catalyzed reactions using molecular oxygen as the oxidant. Chem Soc Rev, 2012, 41: 3381–3430
Wu W, Jiang H. Palladium-catalyzed oxidation of unsaturated hydrocarbons using molecular oxygen. Acc Chem Res, 2012, 45: 1736–1748
Allen SE, Walvoord RR, Padilla-Salinas R, Kozlowski MC. Aerobic copper-catalyzed organic reactions. Chem Rev, 2013, 113: 6234–6458
Ryland BL, Stahl SS. Practical aerobic oxidations of alcohols and amines with homogeneous copper/TEMPO and related catalyst systems. Angew Chem Int Ed, 2014, 53: 8824–8838
Huang X, Li X, Zou M, Song S, Tang C, Yuan Y, Jiao N. From ketones to esters by a Cu-catalyzed highly selective C(CO)-C(alkyl) bond cleavage: aerobic oxidation and oxygenation with air. J Am Chem Soc, 2014, 136: 14858–14865
Tang C, Jiao N. Copper-catalyzed aerobic oxidative C-C bond cleavage for C-N bond formation: from ketones to amides. Angew Chem Int Ed, 2014, 53: 6528–6532
Zhang C, Feng P, Jiao N. Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: an approach to a-ketoesters. J Am Chem Soc, 2013, 135: 15257–15262
Wang T, Jiao N. TEMPO-catalyzed aerobic oxygenation and nitrogenation of olefins via C=C double bond cleavage. J Am Chem Soc, 2013, 135: 11692–11695
Su Y, Sun X, Wu G, Jiao N. Catalyst-controlled highly selective coupling and oxygenation of olefins: a direct approach to alcohols, ketones and diketones. Angew Chem Int Ed, 2013, 52: 9808–9812
Yan Y, Feng P, Zheng QZ, Liang YF, Lu J, Jiao N. PdCl2 and NHPI cocatalyzed Csp2-H hydroxylation via dioxygen activation. Angew Chem Int Ed, 2013, 52: 5827–5831
Liang YF, Jiao N. Highly efficient C-H hydroxylation of carbonyl compounds with oxygen under mild conditions. Angew Chem Int Ed, 2014, 53: 548–552
Godula K, Sames D. C-H bond functionalization in complex organic synthesis. Science, 2006, 312: 67–72
Crabtree RH. Alkane C-H activation and functionalization with homogenous transition metal catalysts: a century of progress—a new millennium in prospect. J Chem Soc Dalton Trans, 2001: 2437–2450
Engle KM, Yu JQ. Transition metal-catalyzed C-H functionalization: synthetically enabling reactions for building molecular complexity. In: Ding K, Dai LX, Eds. Organic Chemistry-Breakthroughs and Perspectives. Weinheim: Wiley, 2012
Li BJ, Shi ZJ. From C(sp2)-H to C(sp3)-H: systematic studies on transition metal-catalyzed oxidative C-C formation. Chem Soc Rev, 2012, 41: 5588–5598
Engle KM, Mei TS, Wasa M, Yu JQ. Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions. Acc Chem Res, 2012, 45: 788–802
Neufeldt SR, Sanford MS. Controlling site selectivity in palladium-catalyzed C-H bond functionalization. Acc Chem Res, 2012, 45: 936–946
Wencel-Delord J, Glorius F. C-H bond activation enables the rapid construction and late-stage diversification of functional molecules. Nat Chem, 2013, 5: 369–375
Zheng QZ, Jiao N. Transition-metal-catalyzed ketone-directed ortho-C-H functionalization reactions. Tetrahedron Lett, 2014, 55: 1121–1126
Rao Y, Shan G, Yang X. Some recent advances in transition-metal-catalyzed ortho sp2 C-H functionalization using Ru, Rh, and Pd. Sci China Chem, 2014, 57: 930–944
Ichikawa Y, Yamanaka Y, Suzuki N, Naruchi T, Kobayashi O, Tsuruta H. A new process for the production of trimethylhydroquinone. Ind Eng Chem Prod Res Dev, 1979, 18: 373–375
Costantini M, Igersheim F, Krumenacker L. Process for the preparation of 4-hydroxy-2,4,6-trimethyl-2,5-cyclohexadienone. US Patent, 4612401, 1986
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Liang, YF., Wu, K., Liu, Z. et al. CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions. Sci. China Chem. 58, 1334–1339 (2015). https://doi.org/10.1007/s11426-015-5363-4
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DOI: https://doi.org/10.1007/s11426-015-5363-4