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Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities

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Abstract

Tetronate antibiotics, a growing family of natural products featuring a characteristic tetronic acid moiety, are of importance and of particular interest for their typical structures, especially the spirotetronate structure, and corresponding versatile biological activities. Considerable efforts have persistently performed since the first tetronate was isolated, to elucidate the biosynthesis of natural tetronate products, by isotope-labeled feeding experiments, genetical characterization of biosynthetic gene clusters, and biochemical reconstitution of key enzymatic catalyzed reactions. Accordingly, the biosynthesis of spirotetronates has been gradually determined, including biosynthesis of a polyketide-derived backbone for spirotetronate aglycone, incorporation of a glycerol-derived three-carbon unit into tetronic acid moiety, formation of mature aglycone via Diels-Alder-like reaction, and decorations of aglycone with various deoxysugar moieties. In this paper, the biosynthetic investigations of natural tetronates are well documented and a common biosynthetic route for this group of natural products is summarized accordingly.

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Authors and Affiliations

  1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China

    WeiXin Tao, MangHong Zhu, ZiXin Deng & YuHui Sun

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  1. WeiXin Tao
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  2. MangHong Zhu
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  3. ZiXin Deng
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Correspondence to YuHui Sun.

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Tao, W., Zhu, M., Deng, Z. et al. Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities. Sci. China Chem. 56, 1364–1371 (2013). https://doi.org/10.1007/s11426-013-4921-x

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  • DOI: https://doi.org/10.1007/s11426-013-4921-x

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