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Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative

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Abstract

The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess (up to 99%).

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  1. State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering; Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, 550025, China

    Ming He, ZhaoXi Pan, Song Bai, Pei Li, YuPing Zhang, LinHong Jin, DeYu Hu, Song Yang & BaoAn Song

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  1. Ming He
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  2. ZhaoXi Pan
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  3. Song Bai
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He, M., Pan, Z., Bai, S. et al. Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative. Sci. China Chem. 56, 321–328 (2013). https://doi.org/10.1007/s11426-012-4822-4

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