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Metal complexes of a novel bis-β-diketone-type ligand and its copper(II) complexes of two-photon biological imaging

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Abstract

A curcumin derivative ligand, 1,7-bis(3-methoxyl-4-acetoxyl)phenyl-1,6-heptadiene-3,5-diketone (diacetylcurcumin, abbreviated as HL), and its Cu and Ni complexes have been synthesized and fully characterized by elemental analyses, IR, 1HNMR and molar conductivity. The resulting complexes exhibit two-photon excited fluorescence (TPEF) in DMF, and have been proven to be potentially useful for two-photon microscopy imaging in living cells. In addition, cytotoxicity tests showed that the low-micromolar concentrations of ML2 did not cause significant reduction in cell viability over a period of at least 24 h and should be safe for further biological studies.

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Authors and Affiliations

  1. Anhui Engineering Research Center of Modernized Chinese Medicine, Department of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, 230031, China

    ShuangSheng Zhou, Xuan Xue & Bo Jiang

  2. Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei, 230039, China

    YuPeng Tian

  3. State Key Laboratory of Crystal Materials, Shandong University, Jinan, 502100, China

    YuPeng Tian

Authors
  1. ShuangSheng Zhou
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  2. Xuan Xue
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  3. Bo Jiang
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  4. YuPeng Tian
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Correspondence to ShuangSheng Zhou.

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Zhou, S., Xue, X., Jiang, B. et al. Metal complexes of a novel bis-β-diketone-type ligand and its copper(II) complexes of two-photon biological imaging. Sci. China Chem. 55, 334–340 (2012). https://doi.org/10.1007/s11426-011-4470-0

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  • DOI: https://doi.org/10.1007/s11426-011-4470-0

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