Skip to main content
Log in

Anterior Surgical Treatment of Cervical Spondylotic Myelopathy

Review Article

  • Cervical Spine Symposium
  • Published:
HSS Journal ®

Abstract

Background

Cervical spondylotic myelopathy (CSM) is a common indication for cervical spine surgery. Surgical options include anterior, posterior, or combined procedures each with specific advantages and disadvantages.

Questions/Purposes

This article will provide a description of the various anterior alternatives and discuss the available evidence used in guiding the surgical decision making process with the aim of answering the following questions: (1) What anatomical/disease related factors favor anterior over posterior surgeries? (2) What are the common anterior procedures and how safe and effective are they? (3) What are the most effective options for multilevel CSM? (4) Is there a role for motion preservation? An additional objective is to discuss technical advances that have improved success rates for anterior procedures.

Methods

The PubMed database was searched. Keywords were CSM and anterior surgery. Three hundred eighty two articles were found one hundred three were reviewed. Articles describing anterior cervical techniques were selected along with studies describing the various anterior techniques or comparisons of anterior to posterior techniques.

Results

Anterior decompression and fusion procedures are more effective than posterior procedures for patients with primarily ventrally located compression especially in the presence of cervical kyphosis. ACDF, ACCF, and hybrid combinations are safe and effective treatment options for multilevel CSM. Anterior procedures may be more cost effective and result in significantly improved postoperative quality of life and health-related quality of life measures compared to posterior procedures.

Conclusion

Anterior cervical decompression techniques are safe and effective in the treatment of CSM. Anterior surgeries may be preferable to posterior approaches, when considering health-related quality of life measures and cost effectiveness.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Acosta FL Jr, Aryan HE, Chou D, et al. Long-term biomechanical stability and clinical improvement after extended multilevel corpectomy and circumferential reconstruction of the cervical spine using titanium mesh cages. J Spinal Disord Tech. 2008; 21(3): 165-174. doi:10.1097/BSD.0b013e3180654205.

    Article  PubMed  Google Scholar 

  2. Ashkenazi E, Smorgick Y, Rand N, et al. Anterior decompression combined with corpectomies and discectomies in the management of multilevel cervical myelopathy: a hybrid decompression and fixation technique. J Neurosurg Spine. 2005; 3(3): 205-209.

    Article  PubMed  Google Scholar 

  3. Ashkenazi E, Smorgick Y, Rand N, et al. Anterior decompression combined with corpectomies and discectomies in the management of multilevel cervical myelopathy: a hybrid decompression and fixation technique. J Neurosurg Spine. 2005; 3(3): 205-209. doi:10.3171/spi.2005.3.3.0205.

    Article  PubMed  Google Scholar 

  4. Banwart JC, Asher MA, Hassanein RS. Iliac crest bone graft harvest donor site morbidity: a statistical evaluation. Spine. 1995; 20(9): 1055-1060.

    Article  CAS  PubMed  Google Scholar 

  5. Barbagallo GM, Romano D, Certo F, et al. Zero-P: a new zero-profile cage-plate device for single and multilevel ACDF. A single institution series with four years maximum follow-up and review of the literature on zero-profile devices. Eur Spine J. 2013; 22(6): 868-878.

    Article  PubMed Central  Google Scholar 

  6. Boakye M, Patil CG, Santarelli J, et al. Cervical spondylotic myelopathy: complications and outcomes after spinal fusion. Neurosurgery. 2008; 62(2): 455-461. doi:10.1227/01.neu.0000316013.97926.4c. discussion 61-2.

    Article  PubMed  Google Scholar 

  7. Brodke DS, KlimoJr P, Bachus KN, et al. Anterior cervical fixation: analysis of load-sharing and stability with use of static and dynamic plates. J Bone Joint Surg. 2006; 88(7): 1566-1573.

    Article  PubMed  Google Scholar 

  8. Chang SW, Kakarla UK, Maughan PH, et al. Four-level anterior cervical discectomy and fusion with plate fixation: radiographic and clinical results. Neurosurgery. 2010; 66(4): 639-646. doi:10.1227/01.NEU.0000367449.60796.94. discussion 46-7.

    Article  PubMed  Google Scholar 

  9. Dalbayrak S, Yilmaz M, Naderi S. “Skip” corpectomy in the treatment of multilevel cervical spondylotic myelopathy and ossified posterior longitudinal ligament: technical note. J Neurosurg Spine. 2010; 12(1): 33-38.

    Article  PubMed  Google Scholar 

  10. DuBois CM, Bolt PM, Todd AG, et al. Static versus dynamic plating for multilevel anterior cervical discectomy and fusion. Spine J. 2007; 7(2): 188-193. doi:10.1016/j.spinee.2006.07.004.

    Article  PubMed  Google Scholar 

  11. Emery SE, Bolesta MJ, Banks MA, et al. Robinson anterior cervical fusion comparison of the standard and modified techniques. Spine (Phila Pa 1976). 1994; 19(6): 660-663.

    Article  CAS  Google Scholar 

  12. Fehlings MG, Smith JS, Kopjar B, et al. Perioperative and delayed complications associated with the surgical treatment of cervical spondylotic myelopathy based on 302 patients from the AOSpine North America Cervical Spondylotic Myelopathy Study. J Neurosurg Spine. 2012; 16(5): 425-432. doi:10.3171/2012.1.SPINE11467.

    Article  PubMed  Google Scholar 

  13. Fehlings MG, Wilson JR, Kopjar B, et al. Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study. J Bone Joint Surg Am. 2013; 95(18): 1651-1658. doi:10.2106/JBJS.L.00589.

    Article  PubMed  Google Scholar 

  14. Fogel GR, Liu W, Reitman CA, et al. Cervical plates: comparison of physical characteristics and in vitro pushout strength. Spine J. 2003; 3(2): 118-124.

    Article  PubMed  Google Scholar 

  15. Fraser JF, Hartl R. Anterior approaches to fusion of the cervical spine: a metaanalysis of fusion rates. J Neurosurg Spine. 2007; 6(4): 298-303. doi:10.3171/spi.2007.6.4.2.

    Article  PubMed  Google Scholar 

  16. Geck MJ, Eismont FJ. Surgical options for the treatment of cervical spondylotic myelopathy. Orthop Clin N Am. 2002; 33(2): 329-348.

    Article  Google Scholar 

  17. Ghogawala Z, Martin B, Benzel EC, et al. Comparative effectiveness of ventral vs dorsal surgery for cervical spondylotic myelopathy. Neurosurgery. 2011; 68(3): 622-630. doi:10.1227/NEU.0b013e31820777cf. discussion 30-1.

    Article  PubMed  Google Scholar 

  18. Gore DR, Sepic SB. Anterior cervical fusion for degenerated or protruded discs: a review of one hundred forty-six patients. Spine. 1984; 9(7): 667-671.

    Article  CAS  PubMed  Google Scholar 

  19. Groff MW, Sriharan S, Lee SM, et al. Partial corpectomy for cervical spondylosis. Spine (Phila Pa 1976). 2003; 28(1): 14-20. doi:10.1097/01.BRS.0000038154.64168.BF.

    Article  Google Scholar 

  20. Guo Q, Bi X, Ni B, et al. Outcomes of three anterior decompression and fusion techniques in the treatment of three-level cervical spondylosis. Eur Spine J. 2011; 20(9): 1539-1544. doi:10.1007/s00586-011-1735-4.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Hida K, Iwasaki Y, Ushikoshi S, et al. Corpectomy: a direct approach to perimedullary arteriovenous fistulas of the anterior cervical spinal cord. J Neurosurg. 2002; 96(2 Suppl): 157-161.

    PubMed  Google Scholar 

  22. Hilibrand AS, Carlson GD, Palumbo MA, et al. Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am. 1999; 81(4): 519-528.

    CAS  PubMed  Google Scholar 

  23. Hofstetter CC, Kesavabhotla K, Boockvar JA. Zero-profile anchored spacer reduces rate of dysphagia compared to ACDF with anterior plating. J Spinal Disord Tech. 2013. doi:10.1097/BSD.0b013e31828873ed.

  24. Hussain M, Nassr A, Natarajan RN, et al. Biomechanical effects of anterior, posterior, and combined anterior-posterior instrumentation techniques on the stability of a multilevel cervical corpectomy construct: a finite element model analysis. Spine J. 2011; 11(4): 324-330. doi:10.1016/j.spinee.2011.02.008.

    Article  PubMed  Google Scholar 

  25. Iwasaki M, Okuda S, Miyauchi A, et al. Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: part 2: advantages of anterior decompression and fusion over laminoplasty. Spine (Phila Pa 1976). 2007; 32(6): 654-660. doi:10.1097/01.brs.0000257566.91177.cb.

    Article  Google Scholar 

  26. Kadoya S, Nakamura T, Kwak R. A microsurgical anterior osteophytectomy for cervical spondylotic myelopathy. Spine (Phila Pa 1976). 1984; 9(5): 437-441.

    Article  CAS  Google Scholar 

  27. Klineberg E. Cervical spondylotic myelopathy: a review of the evidence. Orthop Clin N Am. 2010; 41(2): 193-202. doi:10.1016/j.ocl.2009.12.010.

    Article  Google Scholar 

  28. Koller H, Reynolds J, Zenner J, et al. Mid-to long-term outcome of instrumented anterior cervical fusion for subaxial injuries. Eur Spine J. 2009; 18(5): 630-653.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Lebl DR, Hughes A, Cammisa FP Jr, et al. Cervical spondylotic myelopathy: pathophysiology, clinical presentation, and treatment. HSS J. 2011; 7(2): 170-178. doi:10.1007/s11420-011-9208-1.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Lin Q, Zhou X, Wang X, et al. A comparison of anterior cervical discectomy and corpectomy in patients with multilevel cervical spondylotic myelopathy. Eur Spine J. 2012; 21(3): 474-481. doi:10.1007/s00586-011-1961-9.

    Article  PubMed Central  PubMed  Google Scholar 

  31. Liu T, Xu W, Cheng T, et al. Anterior versus posterior surgery for multilevel cervical myelopathy, which one is better? A systematic review. Eur Spine J. 2011; 20(2): 224-235. doi:10.1007/s00586-010-1486-7.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Liu Y, Qi M, Chen H, et al. Comparative analysis of complications of different reconstructive techniques following anterior decompression for multilevel cervical spondylotic myelopathy. Eur Spine J. 2012; 21(12): 2428-2435. doi:10.1007/s00586-012-2323-y.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Lu J, Wu X, Li Y, et al. Surgical results of anterior corpectomy in the aged patients with cervical myelopathy. Eur Spine J. 2008; 17(1): 129-135. doi:10.1007/s00586-007-0518-4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  34. Matz PG, Holly LT, Mummaneni PV, et al. Anterior cervical surgery for the treatment of cervical degenerative myelopathy. J Neurosurg Spine. 2009; 11(2): 170-173. doi:10.3171/2009.3.SPINE08724.

    Article  PubMed  Google Scholar 

  35. Matz PG, Holly LT, Mummaneni PV, et al. Anterior cervical surgery for the treatment of cervical degenerative myelopathy. J Neurosurg Spine. 2009; 11(2): 170-173. doi:10.3171/2009.3.SPINE08724.

    Article  PubMed  Google Scholar 

  36. Matz PG, Pritchard PR, Hadley MN. Anterior cervical approach for the treatment of cervical myelopathy. Neurosurgery. 2007; 60(1 Supp1 1): S64-S70. doi:10.1227/01.NEU.0000215399.67006.05.

    PubMed  Google Scholar 

  37. Oh MC, Zhang HY, Park JY, et al. Two-level anterior cervical discectomy versus one-level corpectomy in cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2009; 34(7): 692-696. doi:10.1097/BRS.0b013e318199690a.

    Article  Google Scholar 

  38. Papadopoulos EC, Huang RC, Girardi FP, et al. Three-level anterior cervical discectomy and fusion with plate fixation: radiographic and clinical results. Spine (Phila Pa 1976). 2006; 31(8): 897-902. doi:10.1097/01.brs.0000209348.17377.be.

    Article  Google Scholar 

  39. Park JB, Cho YS, Riew KD. Development of adjacent-level ossification in patients with an anterior cervical plate. J Bone Joint Surg Am. 2005; 87(3): 558-563. doi:10.2106/JBJS.C.01555.

    Article  PubMed  Google Scholar 

  40. Park SB, Jahng TA, Chung CK. Remodeling of adjacent spinal alignments following cervical arthroplasty and anterior discectomy and fusion. Eur Spine J. 2012; 21(2): 322-327. doi:10.1007/s00586-011-2000-6.

    Article  PubMed Central  PubMed  Google Scholar 

  41. Park Y, Maeda T, Cho W, et al. Comparison of anterior cervical fusion after two-level discectomy or single-level corpectomy: sagittal alignment, cervical lordosis, graft collapse, and adjacent-level ossification. Spine J. 2010; 10(3): 193-199. doi:10.1016/j.spinee.2009.09.006.

    Article  PubMed  Google Scholar 

  42. Porter RW, Crawford NR, Chamberlain RH, et al. Biomechanical analysis of multilevel cervical corpectomy and plate constructs. J Neurosurg Spine. 2003; 99(1): 98-103.

    Article  Google Scholar 

  43. Rao RD, Currier BL, Albert TJ, et al. Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. J Bone Joint Surg Am. 2007; 89(6): 1360-1378.

    PubMed  Google Scholar 

  44. Riew KD. Surgical management of cervical myelopathy. J Neurol Sci (Turkish). 2005; 22(4): 359-373.

    Google Scholar 

  45. Riew KD, Buchowski JM, Sasso R, et al. Cervical disc arthroplasty compared with arthrodesis for the treatment of myelopathy. J Bone Joint Surg Am. 2008; 90(11): 2354-2364. doi:10.2106/JBJS.G.01608.

    Article  PubMed  Google Scholar 

  46. Robertson JT, Papadopoulos SM, Traynelis VC. Assessment of adjacent-segment disease in patients treated with cervical fusion or arthroplasty: a prospective 2-year study. J Neurosurg Spine. 2005; 3(6): 417-423. doi:10.3171/spi.2005.3.6.0417.

    Article  PubMed  Google Scholar 

  47. Ryu SI, Mitchell M, Kim DH. A prospective randomized study comparing a cervical carbon fiber cage to the Smith-Robinson technique with allograft and plating: up to 24 months follow-up. Eur Spine J. 2006; 15(2): 157-164.

    Article  PubMed Central  PubMed  Google Scholar 

  48. Samartzis D, Shen FH, Matthews DK, et al. Comparison of allograft to autograft in multilevel anterior cervical discectomy and fusion with rigid plate fixation. Spine J. 2003; 3(6): 451-459.

    Article  PubMed  Google Scholar 

  49. Sasso RC, Ruggiero RA Jr, Reilly TM, et al. Early reconstruction failures after multilevel cervical corpectomy. Spine (Phila Pa 1976). 2003; 28(2): 140-142. doi:10.1097/01.BRS.0000041590.90290.56.

    Article  Google Scholar 

  50. Scholz M, Reyes PM, Schleicher P, et al. A new stand-alone cervical anterior interbody fusion device: biomechanical comparison with established anterior cervical fixation devices. Spine (Phila Pa 1976). 2009; 34(2): 156-160. doi:10.1097/BRS.0b013e31818ff9c4.

    Article  Google Scholar 

  51. Scholz M, Schnake KJ, Pingel A, et al. A new zero-profile implant for stand-alone anterior cervical interbody fusion. Clin Orthop Relat Res. 2011; 469(3): 666-673. doi:10.1007/s11999-010-1597-9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  52. Sekhon LH. Two-level artificial disc placement for spondylotic cervical myelopathy. J Clin Neurosci. 2004; 11(4): 412-415. doi:10.1016/j.jocn.2003.10.001.

    Article  PubMed  Google Scholar 

  53. Sekhon LH. Cervical arthroplasty in the management of spondylotic myelopathy: 18-month results. Neurosurg Focus. 2004; 17(3): E8.

    Article  PubMed  Google Scholar 

  54. Shamji MF, Massicotte EM, Traynelis VC, et al. Comparison of anterior surgical options for the treatment of multilevel cervical spondylotic myelopathy: a systematic review. Spine (Phila Pa 1976). 2013; 38(22 Suppl 1): S195-S209. doi:10.1097/BRS.0b013e3182a7eb27.

    Article  Google Scholar 

  55. Shin DA, Yi S, Yoon Do H, et al. Artificial disc replacement combined with fusion versus two-level fusion in cervical two-level disc disease. Spine (Phila Pa 1976). 2009; 34(11): 1153-1159. doi:10.1097/BRS.0b013e31819c9d39. discussion 60-1.

    Article  Google Scholar 

  56. Siemionow KB, Neckrysh S. Anterior approach for complex cervical spondylotic myelopathy. Orthop Clin N Am. 2012; 43(1): 41-52. doi:10.1016/j.ocl.2011.09.002. viii.

    Article  Google Scholar 

  57. Silber JS, Anderson DG, Daffner SD, et al. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine. 2003; 28(2): 134-139.

    Article  PubMed  Google Scholar 

  58. Singh K, Vaccaro AR, Kim J, et al. Enhancement of stability following anterior cervical corpectomy: a biomechanical study. Spine. 2004; 29(8): 845-849.

    Article  PubMed  Google Scholar 

  59. Singh K, Vaccaro AR, Kim J, et al. Enhancement of stability following anterior cervical corpectomy: a biomechanical study. Spine (Phila Pa 1976). 2004; 29(8): 845-849.

    Article  Google Scholar 

  60. Sodeyama T, Goto S, Mochizuki M, et al. Effect of decompression enlargement laminoplasty for posterior shifting of the spinal cord. Spine (Phila Pa 1976). 1999; 24(15): 1527-1531. discussion 31-2.

    Article  CAS  Google Scholar 

  61. Song KJ, Lee KB, Song JH. Efficacy of multilevel anterior cervical discectomy and fusion versus corpectomy and fusion for multilevel cervical spondylotic myelopathy: a minimum 5-year follow-up study. Eur Spine J. 2012; 21(8): 1551-1557. doi:10.1007/s00586-012-2296-x.

    Article  PubMed Central  PubMed  Google Scholar 

  62. Song KJ, Yoon SJ, Lee KB. Three- and four-level anterior cervical discectomy and fusion with a PEEK cage and plate construct. Eur Spine J. 2012; 21(12): 2492-2497. doi:10.1007/s00586-012-2447-0.

    Article  PubMed Central  PubMed  Google Scholar 

  63. Stulik J, Pitzen TR, Chrobok J, et al. Fusion and failure following anterior cervical plating with dynamic or rigid plates: 6-months results of a multi-centric, prospective, randomized, controlled study. Eur Spine J. 2007; 16(10): 1689-1694.

    Article  PubMed Central  PubMed  Google Scholar 

  64. Suda K, Abumi K, Ito M, et al. Local kyphosis reduces surgical outcomes of expansive open-door laminoplasty for cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2003; 28(12): 1258-1262. doi:10.1097/01.BRS.0000065487.82469.D9.

    Google Scholar 

  65. Tang JA, Scheer JK, Smith JS, et al. The impact of standing regional cervical sagittal alignment on outcomes in posterior cervical fusion surgery. Neurosurgery. 2012; 71(3): 662-669. doi:10.1227/NEU.0b013e31826100c9. discussion 9.

    Article  PubMed  Google Scholar 

  66. Uchida K, Nakajima H, Sato R, et al. Cervical spondylotic myelopathy associated with kyphosis or sagittal sigmoid alignment: outcome after anterior or posterior decompression. J Neurosurg Spine. 2009; 11(5): 521-528. doi:10.3171/2009.2.SPINE08385.

    Article  PubMed  Google Scholar 

  67. Uribe JS, Sangala JR, Duckworth EA, et al. Comparison between anterior cervical discectomy fusion and cervical corpectomy fusion using titanium cages for reconstruction: analysis of outcome and long-term follow-up. Eur Spine J. 2009; 18(5): 654-662.

    Article  PubMed Central  PubMed  Google Scholar 

  68. Vaccaro AR, Falatyn SP, Scuderi GJ, et al. Early failure of long segment anterior cervical plate fixation. J Spinal Disord. 1998; 11(5): 410-415.

    Article  CAS  PubMed  Google Scholar 

  69. Wang JC, Hart RA, Emery SE, et al. Graft migration or displacement after multilevel cervical corpectomy and strut grafting. Spine (Phila Pa 1976). 2003; 28(10): 1016-1021. doi:10.1097/01.BRS.0000061998.62204.D7. discussion 21-2.

    Google Scholar 

  70. Wang JC, McDonough PW, Endow K, et al. The effect of cervical plating on single-level anterior cervical discectomy and fusion. J Spinal Disord Tech. 1999; 12(6): 467-471.

    CAS  Google Scholar 

  71. Wang JC, McDonough PW, Endow KK, et al. Increased fusion rates with cervical plating for two-level anterior cervical discectomy and fusion. Spine (Phila Pa 1976). 2000; 25(1): 41-45.

    Article  CAS  Google Scholar 

  72. Wang JC, McDonough PW, Endow KK, et al. Increased fusion rates with cervical plating for two-level anterior cervical discectomy and fusion. Spine. 2000; 25(1): 41.

    Article  CAS  PubMed  Google Scholar 

  73. Wang JC, McDonough PW, Kanim LE, et al. Increased fusion rates with cervical plating for three-level anterior cervical discectomy and fusion. Spine. 2001; 26(6): 643-646.

    Article  CAS  PubMed  Google Scholar 

  74. Yonenobu K, Hosono N, Iwasaki M, et al. Laminoplasty versus subtotal corpectomy. A comparative study of results in multisegmental cervical spondylotic myelopathy. Spine (Phila Pa 1976). 1992; 17(11): 1281-1284.

    Article  CAS  Google Scholar 

Download references

Disclosures

Conflict of Interest

John C. Quinn, MD, Paul D. Kiely MCh, FRCh and Darren R. Lebl, MD have declared no conflict of interest. Alexander P. Hughes, MD reports personal fees and grants from NuVasive, outside the submitted work.

Human/Animal Rights

This article does not contain any studies with human or animal subjects performed by the any of the authors.

Informed Consent

N/A

Required Author Forms

Disclosure forms provided by the authors are available with the online version of this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John C. Quinn MD.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

ESM 1

(PDF 1224 kb)

ESM 2

(PDF 1225 kb)

ESM 3

(PDF 1225 kb)

ESM 4

(PDF 1224 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Quinn, J.C., Kiely, P.D., Lebl, D.R. et al. Anterior Surgical Treatment of Cervical Spondylotic Myelopathy. HSS Jrnl 11, 15–25 (2015). https://doi.org/10.1007/s11420-014-9408-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11420-014-9408-6

Keywords

Navigation