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Two new antimalarial quassinoid derivatives from the stems of Brucea javanica

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Abstract

Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3–8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC50 values of 1.41 and 1.06 μM, respectively.

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Acknowledgements

This research was financially supported by the Prince of Songkla University, Thailand. We are grateful to Associate Professor Dr. Surat Laphookhieo, School of Science, Mae Fah Luang University for giving valuable suggestions and Associate Professor Dr. Seppo Karrila, Faculty of Science and Industrial Technology, Prince of Songkla University, for the helpful comments and suggestions on our draft manuscript.

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Authors and Affiliations

  1. Faculty of Science and Industrial Technology, Prince of Songkla University, Suratthani Campus, Suratthani, 84000, Thailand

    Parinuch Chumkaew, Jaraslak Pechwang & Theera Srisawat

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  1. Parinuch Chumkaew
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  2. Jaraslak Pechwang
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  3. Theera Srisawat
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Correspondence to Parinuch Chumkaew.

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Chumkaew, P., Pechwang, J. & Srisawat, T. Two new antimalarial quassinoid derivatives from the stems of Brucea javanica . J Nat Med 71, 570–573 (2017). https://doi.org/10.1007/s11418-017-1089-2

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  • DOI: https://doi.org/10.1007/s11418-017-1089-2

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