Abstract
Four new alkaloids, hemerocallisamines IV–VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV–VI was elucidated by the application of the modified Mosher’s method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of Aβ42 in vitro. This is the first report about bioactive alkaloids with a γ-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.
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Acknowledgments
This work was supported in part by a grant-in-aid for scientific research from the Japan Society for the Promotion of Science [JSPS KAKENHI (Grant-in-Aid for JSPS Fellows, 15J07730 to M.T.) (Grant-in-Aid for Scientific Research (C), 26460135 to N.S.)]. M.T. is grateful for the Research Fellowships for Young Scientists from JSPS.
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Matsumoto, T., Nakamura, S., Nakashima, S. et al. γ-Lactam alkaloids from the flower buds of daylily. J Nat Med 70, 376–383 (2016). https://doi.org/10.1007/s11418-015-0963-z
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DOI: https://doi.org/10.1007/s11418-015-0963-z