Abstract
Three new taxoids (1–3), along with three known taxoids (4–6), were isolated from a EtOAc extract of Taxus cuspidata seed. The structures of 1–3 were determined by analyses of spectroscopic data.
References
Kingston D, Molinero A, Rimoldi J (1993) The taxane diterpenoids. Prog Chem Org Nat Prod 61:1–206
Balogle E, Kingston D (1999) The taxane diterpenoids. J Nat Prod 62(10):1448–1472
Wang LY, Bai LM, Tokunaga D, Watanabe Y, Sakai J, Tang WX, Bai YH, Hirose, Ando M (2008) Two new taxoids from the needles and young stems of Taxus cuspidata. Heterocycles 75:911–917
Wang LY, Bai LM, Tokunaga D, Watanabe Y, Hasegawa Y, Sakai J, Tang WX, Bai YH, Hirose, Takao KY, Tomida A, Tsuruo T, Ando M (2008) The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity. J Wood Sci 54:390–401
Kobayashi J, Ogiwara A, Hosoyama H, Sigemori H, Yoshida N, Sasaki T, Li Y, Iwasaki S, Naito M, Tsuruo T (1994) Taxuspines A–C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron 50:7401–7416
Appendino G, Lusso P, Gariboldi P, Bombardelli E, Gabetta B (1992) A 3,11-cyclotaxane from Taxus baccata. Phytochemistry 31:4259–4262
Kobayashi T, Kurono M, Sato H, Nakanishi K (1972) Nature of photochemically induced transannular hydrogen abstraction of taxinines. J Am Chem Soc 19:2863–2865
Kobayashi J, Inubushi A, Hosoyama H, Yoshida N, Sasaki T, Shigemori H (1995) Taxuspines E–H and J, new taxoids from the Japanese yew Taxus cuspidata. Tetrahedron 51:5971–5978
Shi QW, Oritani T, Sugiyama T, Oritani T (2000) Three new taxane diterpenoids from the seeds of the Japanese yew, Taxus cuspidata. Nat Prod Res 14(4):265–272
Appendino G, Ozen HC, Fenoglio I, Garboldi P, Gabetta B, Bombardelli E (1993) Pseudoalkaloid taxanes from Taxus baccata. Phytochemistry 33:1521–1523
Acknowledgments
This research was supported by Program for the Overseas Scholars Foundation of the Ministry of Education (2010[609]); the Overseas Scholars Foundation of Scientific and Technical Agency of Heilongjiang province Foundation of China (No. LC2011C17); and Scientific and Technical Agency of Heilongjiang province Foundation of China (No. B201116).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, Ly., Ding, Lm., Huo, Sc. et al. Three new taxoids from the seed of Taxus cuspidata . J Nat Med 67, 827–832 (2013). https://doi.org/10.1007/s11418-012-0731-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11418-012-0731-2