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Anti-angiogenic effect of α-mangostin

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Abstract

Eleven known prenyl xanthones, isolated from the pericarp of Garcinia mangostana, were tested for their ability to inhibit the phosphorylation of kinase domain receptor (KDR) tyrosine kinase. α-Mangostin was found to inhibit phosphorylation of KDR. α-Mangostin also showed to inhibit phosphorylation of the Y1175 residue of KDR (10 μM). This is the first report that α-mangostin inhibited the phosphorylation of KDR tyrosine kinase and also the Y1175 residue of KDR. α-Mangostin also showed inhibitory effects on proliferation of human umbilical vein endothelial cells (HUVECs) (IC50 1.2 μM) and human umbilical artery endothelial cells (IC50 2.4 μM), as well as the migration (IC50 0.034 μM) and tubule formation (at the concentrations of 0.6 and 1.2 μM) of HUVECs. These results suggest that the inhibition of the phosphorylation of KDR tyrosine kinase is concerned in the anti-angiogenic activity of α-mangostin.

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Acknowledgments

This research was partially supported by the Japan Society for the Promotion of Science (JSPS) AA Scientific Platform Program (2010–2012) and a grant from the High-Tech Research Center Project, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (S0801043).

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Authors and Affiliations

  1. Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan

    Tomoko Shiozaki, Miyuki Fukai, Kaoru Kinoshita, Kunio Takahashi & Kiyotaka Koyama

  2. Department of Chemistry, Bandung Institute of Technology, Jalan Ganeca 10, Bandung, 40132, Indonesia

    Elvira Hermawati, Lia Dewi Juliawaty, Yana Maolana Syah & Euis Holisotan Hakim

  3. Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand

    Ploenthip Puthongking

  4. Department of Analytical Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan

    Toshihiro Suzuki

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  1. Tomoko Shiozaki
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  2. Miyuki Fukai
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  3. Elvira Hermawati
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Correspondence to Kiyotaka Koyama.

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Shiozaki, T., Fukai, M., Hermawati, E. et al. Anti-angiogenic effect of α-mangostin. J Nat Med 67, 202–206 (2013). https://doi.org/10.1007/s11418-012-0645-z

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  • DOI: https://doi.org/10.1007/s11418-012-0645-z

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