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Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery

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Abstract

A cyclic depsipeptide, FR900359, isolated from Ardisia crenata was evaluated for vasorelaxant effects on rat aortic arteries. FR900359 caused concentration-dependent relaxation (1 nM–10 μM) in phenylephrine-precontracted endothelium-intact aortic rings, which was inhibited by addition of l-NMMA, a NOS inhibitor. In endothelium-denuded rings, the relaxant effect of low concentrations of FR900359 was diminished, but remained at high concentrations. In endothelium-denuded rings, FR900359 at 0.1 μM significantly attenuated high-K+-induced contractions and completely inhibited Ca2+-induced contractions. These results suggest that the vasorelaxant effect of FR900359 is mediated through the increased release of NO from endothelial cells at low concentrations, and can be attributed to inhibitory effects on voltage-dependent Ca2+ channel- and receptor-operated Ca2+ channel-dependent Ca2+ influx at high concentrations.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and a grant from The Open Research Center Project in Hoshi University.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Kazumasa Zaima, Jun Deguchi, Yosuke Matsuno, Toshio Kaneda, Yusuke Hirasawa & Hiroshi Morita

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  1. Kazumasa Zaima
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  2. Jun Deguchi
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  3. Yosuke Matsuno
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  4. Toshio Kaneda
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  5. Yusuke Hirasawa
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Correspondence to Hiroshi Morita.

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Zaima, K., Deguchi, J., Matsuno, Y. et al. Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery. J Nat Med 67, 196–201 (2013). https://doi.org/10.1007/s11418-012-0644-0

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  • DOI: https://doi.org/10.1007/s11418-012-0644-0

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