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Antiplasmodial decarboxyportentol acetate and 3,4-dehydrotheaspirone from Laumoniera bruceadelpha

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Abstract

A new spiro heterocycle, decarboxyportentol acetate (1) was isolated from the barks of Laumoniera bruceadelpha Nooteboom (Simaroubaceae), together with 3,4-dehydrotheaspirone (2), and their structures were elucidated by 2D NMR analysis. 3,4-Dehydrotheaspirone (2) showed potent antiplasmodial activity against Plasmodium falciparum 3D7.

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Fig. 1
Fig. 2

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Acknowledgments

This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant from the Open Research Center Project.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan

    Hiroshi Morita, Reika Mori, Jun Deguchi, Shiori Oshimi & Yusuke Hirasawa

  2. Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, Indonesia

    Wiwied Ekasari & Aty Widyawaruyanti

  3. Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    A. Hamid A. Hadi

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  1. Hiroshi Morita
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  2. Reika Mori
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  3. Jun Deguchi
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  4. Shiori Oshimi
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  5. Yusuke Hirasawa
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  6. Wiwied Ekasari
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  7. Aty Widyawaruyanti
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  8. A. Hamid A. Hadi
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Correspondence to Hiroshi Morita.

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Morita, H., Mori, R., Deguchi, J. et al. Antiplasmodial decarboxyportentol acetate and 3,4-dehydrotheaspirone from Laumoniera bruceadelpha . J Nat Med 66, 571–575 (2012). https://doi.org/10.1007/s11418-011-0618-7

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  • DOI: https://doi.org/10.1007/s11418-011-0618-7

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