Abstract
Chemical investigation of a methanolic extract of the seed kernels of Entada rheedei (Fabaceae), a Thai medicinal plant taken for stomachache, led to the isolation of five new compounds, 1-(3,4-dimethoxyphenyl)propan-9-ol O-(6″-O-α-l-arabinopyranosyl)-β-d-glucopyranoside, 1-(3,4,5-trimethoxyphenyl)prop-7-en-9-ol O-(6″-O-α-l-arabinopyranosyl)-β-d-glucopyranoside, and N-(2′-hydroxyethyl)-7-phenylacetamide 2′-O-β-d-glucopyranoside, and entadamide A 2′-O-(4″-O-β-d-glucopyranosyl)-β-d-glucopyranoside and 2′-O-(6″-O-β-d-glucopyranosyl)-β-d-glucopyranosides, together with one known compound, corchoionoside C. Their structures were elucidated on the basis of chemical and spectral evidence.
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References
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Acknowledgments
The authors are grateful for access to the superconducting NMR instrument (JEOL JNM α-400) at the Analytical Center of Molecular Medicine of the Hiroshima University Faculty of Medicine, and the LTQ Orbitrap XL HR-ESI-MS at the Natural Science Center for Basic Research and Development (N-BARD), Hiroshima University. Thanks are also due to the Research Foundation for Pharmaceutical Sciences and the Takeda Science Foundation for the financial support.
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Sugimoto, S., Matsunami, K. & Otsuka, H. Medicinal plants of Thailand. II: chemical studies on the seed kernels of Entada rheedei Sprengel. J Nat Med 66, 552–557 (2012). https://doi.org/10.1007/s11418-011-0608-9
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DOI: https://doi.org/10.1007/s11418-011-0608-9