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Entadosides A–D, triterpene saponins and a glucoside of the sulphur-containing amide from the kernel nuts of Entada phaseoloides (L.) Merrill

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Abstract

From a MeOH extract of kernel nuts of Entada phaseoloides (L.) Merrill, one new and one known sulphur-containing glucoside were isolated. From the 1-BuOH-soluble fraction of a H2O extract, four new triterpene saponins containing N-acetylglucosamine in their sugar chains were isolated. The antiproliferative activities of the triterpene saponins were assayed.

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Acknowledgments

The authors are grateful for access to the superconducting NMR instrument (JEOL α-400) at the Analytical Center of Molecular Medicine and an Applied Biosystem QSTAR XL system ESI (Nano Spray)-MS at the Analysis Center of Life Science of the Graduate School of Biomedical Sciences, Hiroshima University. This work was financially supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Japan Society for the Promotion of Science. Thanks are also due to the Takeda Science Foundation for financial support.

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Authors and Affiliations

  1. Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Yoshihiro Iwamoto, Sachiko Sugimoto, Liva Harinantenaina, Katsuyoshi Matsunami & Hideaki Otsuka

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  1. Yoshihiro Iwamoto
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  2. Sachiko Sugimoto
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  3. Liva Harinantenaina
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  4. Katsuyoshi Matsunami
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  5. Hideaki Otsuka
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Correspondence to Hideaki Otsuka.

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Iwamoto, Y., Sugimoto, S., Harinantenaina, L. et al. Entadosides A–D, triterpene saponins and a glucoside of the sulphur-containing amide from the kernel nuts of Entada phaseoloides (L.) Merrill. J Nat Med 66, 321–328 (2012). https://doi.org/10.1007/s11418-011-0591-1

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  • DOI: https://doi.org/10.1007/s11418-011-0591-1

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