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Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia

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Abstract

We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.

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Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 23590026 to C.I, 2011) from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan

    Chihiro Ito, Keisuke Nakao & Hiroshi Furukawa

  2. Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan

    Tomiyasu Murata & Norio Kaneda

  3. Faculty of Human Wellness, Tokai Gakuen University, 21-233 Nishinohora, Ukigai, Miyoshi, Aichi, 470-0207, Japan

    Masataka Itoigawa

Authors
  1. Chihiro Ito
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  2. Masataka Itoigawa
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  3. Keisuke Nakao
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  4. Tomiyasu Murata
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  5. Norio Kaneda
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  6. Hiroshi Furukawa
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Corresponding author

Correspondence to Masataka Itoigawa.

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Ito, C., Itoigawa, M., Nakao, K. et al. Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia . J Nat Med 66, 357–361 (2012). https://doi.org/10.1007/s11418-011-0584-0

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  • DOI: https://doi.org/10.1007/s11418-011-0584-0

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