Abstract
Trichodermanin A, a structurally unique diterpenoid with skeletal carbons arranged compactly in a fused 6-5-6-6 ring system, has been isolated from cultures of Trichoderma atroviride (strain no. S361), an endophytic fungus isolate in Cephalotaxus fortunei. The structure of this compound was elucidated based on extensive spectroscopic methods and confirmed by X-ray diffraction analysis.
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Notes
Crystallographic data for the structure reported in this paper have been deposited at the Cambridge Crystallographic Data Center as supplementary publication number CCDC 793816. Copies of the data can be obtained, free of charge, on application to the Director, 12 Union Road, Cambridge CB2 1EZ, UK (fax: +44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk)
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Acknowledgments
The authors are grateful to the Shanghai Institute of Organic Chemistry Chinese Academy of Sciences for help with the NMR measurements.
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P.-X. Sun and C.-J. Zheng contributed equally to this work.
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Sun, PX., Zheng, CJ., Li, WC. et al. Trichodermanin A, a novel diterpenoid from endophytic fungus culture. J Nat Med 65, 381–384 (2011). https://doi.org/10.1007/s11418-010-0499-1
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DOI: https://doi.org/10.1007/s11418-010-0499-1