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Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica

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Abstract

A novel α-tetralonyl derivative, juglanone, was isolated from the fresh unripe fruits of Juglans mandshurica. Its structure was determined by spectroscopic analyses and from chemical evidence. Juglanone exhibited significant antioxidant activity in assays for 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and superoxide dismutase-like activity with IC50 values of 10.1 and 9.0 μM, respectively. It also showed moderate cytotoxic activity against HL-60 human myeloid leukemia with an IC50 value of 19.7 μM.

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Acknowledgments

We thank Dr. Yoshio Hano for helpful discussions concerning the manuscript. L. L. is grateful to Youth Fund of Education Department of Heilongjiang Province of China (11531279) and Youth Fund of Science and Technology Department of Heilongjiang Province of China (QC07C65).

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan

    Lijuan Liu, Wei Li, Tatsunori Sasaki & Kazuo Koike

  2. Department of Pharmaceutical Engineering, Heilongjiang University, Harbin, 150080, China

    Lijuan Liu

  3. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan

    Yoshihisa Asada

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  1. Lijuan Liu
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  2. Wei Li
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  3. Tatsunori Sasaki
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  4. Yoshihisa Asada
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  5. Kazuo Koike
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Correspondence to Wei Li.

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Liu, L., Li, W., Sasaki, T. et al. Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica . J Nat Med 64, 496–499 (2010). https://doi.org/10.1007/s11418-010-0435-4

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  • DOI: https://doi.org/10.1007/s11418-010-0435-4

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