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New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L.

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Abstract

Ten flavonoids were isolated from the ethyl acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum and their structures were elucidated on the basis of spectroscopic methods to be 5,7,3′-trihydroxy-5′-methoxylisoflavone (1), biochanin A (2), formononetin (3), irilone (4), tricin (5), daidzein (6), calycosin (7), orientin-2″-O-p-trans-coumarate (8), vitexin-2″-O-p-trans-coumarate (9), and tricin-7-O-β-d-glucopyranoside (10). Compounds 1 and 8 are new flavonoids, and 8 and 9 strongly promoted 2BS cell proliferation induced by H2O2.

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Acknowledgments

The authors are grateful to the Department of Medicinal Analysis, Pharmacy College, Shandong University, for performing NMR, and the Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, for measuring the compound activities in the 2BS cell proliferation assay.

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Authors and Affiliations

  1. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062, China

    Guo-Rong Wang, Wen-Zhao Tang, Qing-Qiang Yao, Hao Zhong & Yong-Jun Liu

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  1. Guo-Rong Wang
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  2. Wen-Zhao Tang
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  3. Qing-Qiang Yao
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  4. Hao Zhong
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  5. Yong-Jun Liu
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Correspondence to Qing-Qiang Yao.

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Wang, GR., Tang, WZ., Yao, QQ. et al. New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L.. J Nat Med 64, 358–361 (2010). https://doi.org/10.1007/s11418-010-0407-8

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  • DOI: https://doi.org/10.1007/s11418-010-0407-8

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