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Free radical scavengers from the aerial parts of Euphorbia petiolata

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Abstract

Reversed-phase preparative high-performance liquid chromatography (HPLC) of the methanol extract of the aerial parts of Euphorbia petiolata Banks & Soland, an endemic Iranian medicinal plant, yielded ten free radical scavengers including eight flavonoid glycosides myricetin 3-O-glucoside (1), kaempferol 3-O-(2-O-galloyl)-glucoside (2), myricetin 3-O-rhamnoside (3), quercetin 3-O-glucoside (4), kaempferol 3-O-glucoside (5), quercetin 3-O-rhamnoside (6), kaempferol 3-O-rhamnoside (7), and quercetin 3-O-rutinoside (10), a coumarin esculetin (8) and a phenylpropanoid 2-hydroxydihydrocinnamic acid (9). The structures of these compounds were elucidated conclusively by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. The free radical scavenging properties of these compounds were assessed by the 2,2-diphenyl-1-picrylhydrazyl assay.

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Acknowledgments

We thank the Talent Students’ Department, University of Tabriz, for financial support.

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Authors and Affiliations

  1. Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Hossein Nazemiyeh & Malakeh Jodari

  2. Talent Students’ Center, University of Tabriz, Tabriz, Iran

    Elham Mohajjel Kazemi & Khadijeh Zare

  3. Drug Discovery and Design Research Division, Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, MA Building, Wulfruna Street, Wolverhampton, West Midland, WV1 1LY, UK

    Lutfun Nahar

  4. Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, MM Building, Molineux Street, Wolverhampton, West Midland, WV1 1SB, UK

    Satyajit Dey Sarker

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  1. Hossein Nazemiyeh
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  2. Elham Mohajjel Kazemi
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  3. Khadijeh Zare
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Correspondence to Satyajit Dey Sarker.

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Nazemiyeh, H., Kazemi, E.M., Zare, K. et al. Free radical scavengers from the aerial parts of Euphorbia petiolata . J Nat Med 64, 187–190 (2010). https://doi.org/10.1007/s11418-009-0382-0

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  • DOI: https://doi.org/10.1007/s11418-009-0382-0

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