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Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice

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Abstract

Brown sugar has been used traditionally for the treatment of skin trouble as a component of soaps or lotions. Symptoms of aging including wrinkles and pigmentation develop earlier in sun-exposed skin than unexposed skin, a phenomenon referred to as photoaging. Ultraviolet B (UVB) radiation is one of the most important environmental factors influencing photoaging. The aim of this study was to clarify whether the nonsugar fraction of brown sugar prevents chronic UVB-induced aging of the skin using melanin-possessing hairless mice. The nonsugar fraction (1% or 3% solution, 50 μl/mouse) was applied topically to the dorsal region every day for 19 weeks. Both solutions prevented an increase in skin thickness and reduction in skin elasticity caused by the UVB. The 3% solution also prevented wrinkles and melanin pigmentation as well as increases in the diameter and length of skin blood vessels. Increases in the expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in UVB-irradiated skin was inhibited by the nonsugar fraction. Prevention of UVB-induced aging of the skin by topical application of the nonsugar fraction of brown sugar may be due to inhibition of increases in MMP-2 and VEGF expression.

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Acknowledgments

This work was supported in part by Grants-in-aid for Scientific Research (C) (No. 19590694; A representative: Maho Sumiyoshi, and No. 20590700; A representative: Yoshiyuki Kimura) from the Ministry of Education, Culture, Sports, Science and Technology, and the Orient Herb Co.

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Authors and Affiliations

  1. Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791-0295, Japan

    Maho Sumiyoshi

  2. Foundation of International Oriental Medical Research, Kawanishi City, Hyogo, 666-0122, Japan

    Teruaki Hayashi

  3. Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791-0295, Japan

    Yoshiyuki Kimura

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  1. Maho Sumiyoshi
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  2. Teruaki Hayashi
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  3. Yoshiyuki Kimura
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Correspondence to Yoshiyuki Kimura.

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Sumiyoshi, M., Hayashi, T. & Kimura, Y. Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice. J Nat Med 63, 130–136 (2009). https://doi.org/10.1007/s11418-008-0301-9

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  • DOI: https://doi.org/10.1007/s11418-008-0301-9

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