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Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis

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Abstract

Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5β-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and β-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H37Rv with a MIC of 64 μg/mL, while squalene and the sterol mixture have MICs of 100 and 128 μg/mL, respectively.

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Acknowledgments

Philippine Council for Advanced Science and Technology Research and Development for the fellowship of M. Tan and the Research Center for the Natural Sciences, UST.

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Authors and Affiliations

  1. Research Center for the Natural Sciences, Graduate School and College of Science, University of Santo Tomas, España, 1015, Manila, Philippines

    Mario A. Tan & Maribel G. Nonato

  2. Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan

    Hiromitsu Takayama, Norio Aimi & Mariko Kitajima

  3. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, IL, 60612-7231, USA

    Scott G. Franzblau

Authors
  1. Mario A. Tan
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  2. Hiromitsu Takayama
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  3. Norio Aimi
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  4. Mariko Kitajima
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  5. Scott G. Franzblau
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  6. Maribel G. Nonato
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Corresponding author

Correspondence to Maribel G. Nonato.

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Tan, M.A., Takayama, H., Aimi, N. et al. Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis . J Nat Med 62, 232–235 (2008). https://doi.org/10.1007/s11418-007-0218-8

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  • DOI: https://doi.org/10.1007/s11418-007-0218-8

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