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Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals

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Abstract

Ethanolic extract of Cissampelos pareira (L.) Hirsuta (Menispermaceae) roots have been examined in various acute and chronic ulcers in validated experimental models in rats. C. pareira extract of 25–100 mg/kg administered orally, twice daily for 5 days showed a dose-dependent, ulcer-protective effect. The extract demonstrated significant protection against 100% ethanol- (P < 0.05), aspirin- (P < 0.001), cold-restraint stress- (P < 0.01) and pylorus ligation- (P < 0.001) induced acute gastric ulcers in rats. A flavonoid Quercetin, isolated from C. pareira, showed significant antiulcer property (P < 0.05 to P < 0.001) against gastric ulcers in different acute models. In chronic ulcers induced by 50% acetic acid, C. pareira significantly (P < 0.001) reduced the ulcer index with decreased perforations after 5- and 10-day treatment. C. pareira significantly enhanced the defense factors as total hexose and sialic acid while significantly reducing the ulcer index in the lipid peroxidase product malondialdehyde in ethanol-induced ulcers.

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Acknowledgment

This study was supported by grants from the Department of Science and Technology, Ministry of Science and Technology, New Delhi (GAP273225 and GAP273525). Authors are highly thankful to Director NBRI, Lucknow, for providing the necessary facilities.

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Authors and Affiliations

  1. Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Post Box No. 436, Lucknow , 226 001, Uttar Pradesh, India

    G. Amresh, Hussain Zeashan, Ram Ji Gupta, Ravi Kant & Chandana Venkateswara Rao

  2. Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221 005, Uttar Pradesh, India

    Paras Nath Singh

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  1. G. Amresh
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  2. Hussain Zeashan
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Correspondence to G. Amresh.

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Amresh, G., Zeashan, H., Gupta, R.J. et al. Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals. J Nat Med 61, 323–328 (2007). https://doi.org/10.1007/s11418-007-0141-z

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  • DOI: https://doi.org/10.1007/s11418-007-0141-z

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