Zusammenfassung
Die Abdomensonographie hat in der Diagnostik und beim therapeutischen Management einer Leberzirrhose einen hohen Stellenwert. Wichtigste Kriterien für die sonographische Diagnose einer Leberzirrhose sind inhomogenes Parenchym, eine unregelmäßige Leberoberfläche und eine Rarefizierung der Lebervenen. Komplikationen, wie die portale Hypertension, Aszites und ein hepatozelluläres Karzinom (HCC), können erfasst werden. Nach Anlage eines transjugulären intrahepatischen portosystemischen Stentshunts (TIPSS) ist die Perfusion des TIPSS und der Pfortader sonographisch zu kontrollieren. Eine Abdomensonographie im Rahmen des HCC-Screenings wird bei Patienten mit Leberzirrhose alle 6 Monate empfohlen. Bei unklarer Leberraumforderung ist die Durchführung einer Kontrastmittelsonographie (CEUS) der nächste Schritt. Standardisierte CEUS-basierte Diagnosealgorithmen können die nichtinvasive Diagnose eines HCC erleichtern.
Abstract
Abdominal ultrasound helps in the diagnostic and therapeutic management of hepatic cirrhosis. Important sonographic criteria for the diagnosis of liver cirrhosis are inhomogeneous parenchyma, irregular liver surface, and rarefication of hepatic veins. Sonography detects complications such as portal hypertension, ascites, or hepatocellular carcinoma (HCC). After implantation of a transjugular intrahepatic portosystemic shunt (TIPSS), sonographic evaluation of perfusion of both TIPSS and portal vein is mandatory. A sonographic screening for HCC is recommended every 6 months in liver cirrhosis and patients at risk. In case of an unclear focal liver lesion, contrast-enhanced ultrasound (CEUS) should be performed. Standardized CEUS-based diagnostic algorithms may facilitate non-invasive diagnosis of HCC.
Literatur
Wiegand J, Berg T (2013) The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis. Dtsch Arztebl Int 110:85–91
Said A, Gagovic V, Malecki K, Givens ML, Nieto FJ (2013) Primary care practitioners survey of non-alcoholic fatty liver disease. Ann Hepatol 12:758–765
Wong RJ, Aguilar M, Cheung R et al (2015) Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology 148:547–555
Spengler EK, Loomba R (2015) Recommendations for diagnosis, referral for liver biopsy, and treatment of nonalcoholic fatty liver disease and nonalcoholic Steatohepatitis. Mayo Clin Proc 90:1233–1246
Pfeifer L, Goertz RS, Sturm J et al (2014) Acoustic radiation force impulse (ARFI) and high-frequency ultrasound of the liver surface for the diagnosis of compensated liver cirrhosis. Ultraschall Med 35:44–50
Cagin YF, Atayan Y, Erdogan MA, Dagtekin F, Colak C (2016) Incidence and clinical presentation of portal vein thrombosis in cirrhotic patients. HBPD INT 15:499–503
Stine JG, Wang J, Shah PM et al (2018) Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study. Liver Int 38:94–101
von Kockritz L, De Gottardi A, Trebicka J, Praktiknjo M (2017) Portal vein thrombosis in patients with cirrhosis. Gastroenterol Rep (Oxf) 5:148–156
Berzigotti A, Piscaglia F (1980) Ultrasound in portal hypertension – part 1. Ultraschall Med 2011(32):548–568 (quiz 69–71)
Knop V (2018) Elastographie in der Routineanwendung – Tipps für die Interpretation bei Anbietervielfalt. Gastroenterologie. https://doi.org/10.1007/s11377-018-0265-6
Goertz RS, Sturm J, Pfeifer L et al (2013) ARFI cut-off values and significance of standard deviation for liver fibrosis staging in patients with chronic liver disease. Ann Hepatol 12:935–941
Bamber J, Cosgrove D, Dietrich CF et al (2013) EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: Basic principles and technology. Ultraschall Med 34:169–184
Ferraioli G, Parekh P, Levitov AB, Filice C (2014) Shear wave elastography for evaluation of liver fibrosis. J Ultrasound Med 33:197–203
Piscaglia F, Salvatore V, Mulazzani L, Cantisani V, Schiavone C (2016) Ultrasound shear wave Elastography for liver disease. A critical appraisal of the many actors on the stage. Ultraschall Med 37:1–5
Friedrich-Rust M, Poynard T, Castera L (2016) Critical comparison of elastography methods to assess chronic liver disease. Nat Rev Gastroenterol Hepatol 13:402–411
Gotz M, Anders M, Biecker E et al (2017) S2k Guideline Gastrointestinal Bleeding – Guideline of the German Society of Gastroenterology DGVS. Z Gastroenterol 55:883–936
Berzigotti A, Piscaglia F (2012) Ultrasound in portal hypertension – part 2 – and EFSUMB recommendations for the performance and reporting of ultrasound examinations in portal hypertension. Ultraschall Med 33:8–32 (quiz 0–1)
Lv Y, He C, Wang Z et al (2017) Association of nonmalignant portal vein thrombosis and outcomes after Transjugular Intrahepatic Portosystemic shunt in patients with cirrhosis. Radiology 285:999–1010
Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69–90
DGVS/AWMF (2013) S3-Leitlinie Hepatozelluläres Karzinom. https://www.dgvs.de/wissen-kompakt/leitlinien/leitlinien-der-dgvs/hepatozellulaeres-karzinom/. Zugegriffen: 01.04.2018
Chen JD, Yang HI, Iloeje UH et al (2010) Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology 138:1747–1754
Seitz K, Greis C, Schuler A et al (2011) Frequency of tumor entities among liver tumors of unclear etiology initially detected by sonography in the noncirrhotic or cirrhotic livers of 1349 patients. Results of the DEGUM multicenter study. Ultraschall Med 32:598–603
Strobel D, Seitz K, Blank W et al (2009) Tumor-specific vascularization pattern of liver metastasis, hepatocellular carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis of 1,349 liver lesions in contrast-enhanced ultrasound (CEUS). Ultraschall Med 30:376–382
Friedrich-Rust M, Klopffleisch T, Nierhoff J et al (2013) Contrast-Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta-analysis. Liver Int 33:739–755
Greten TF, Manns MP (2008) Hepatocellular carcinoma – diagnosis and treatment. Dtsch Med Wochenschr 133:1907–1910
Leoni S, Piscaglia F, Granito A et al (2013) Characterization of primary and recurrent nodules in liver cirrhosis using contrast-enhanced ultrasound: which vascular criteria should be adopted? Ultraschall Med 34:280–287
Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver – update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 34:11–29
Boozari B, Soudah B, Rifai K et al (2011) Grading of hypervascular hepatocellular carcinoma using late phase of contrast enhanced sonography – a prospective study. Dig Liver Dis 43:484–490
Piscaglia F, Wilson SR, Lyshchik A et al (2017) American college of radiology contrast enhanced ultrasound liver imaging reporting and data system (CEUS LI-RADS) for the diagnosis of Hepatocellular carcinoma: a pictorial essay. Ultraschall Med 38:320–324
Mitchell DG, Bruix J, Sherman M, Sirlin CB (2015) LI-RADS (Liver Imaging Reporting and Data System): summary, discussion, and consensus of the LI-RADS Management Working Group and future directions. Hepatology 61:1056–1065
Schellhaas B, Gortz RS, Pfeifer L et al (2017) Diagnostic accuracy of contrast-enhanced ultrasound for the differential diagnosis of hepatocellular carcinoma: ESCULAP versus CEUS-LI-RADS. Eur J Gastroenterol Hepatol 29:1036–1044
Schellhaas B, Wildner D, Pfeifer L et al (2016) LI-RADS-CEUS – proposal for a contrast-enhanced ultrasound algorithm for the diagnosis of Hepatocellular carcinoma in high-risk populations. Ultraschall Med 37:627–634
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R.S. Görtz und B. Schellhaas geben an, dass kein Interessenkonflikt besteht.
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M. Friedrich-Rust, Frankfurt
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Görtz, R.S., Schellhaas, B. Sonographie bei Leberzirrhose: von der TIPSS-Funktionsprüfung zur LI-RADS®-Klassifikation. Gastroenterologe 13, 292–297 (2018). https://doi.org/10.1007/s11377-018-0270-9
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DOI: https://doi.org/10.1007/s11377-018-0270-9
Schlüsselwörter
- Diagnostischer Ultraschall
- Kontrastmittelsonographie (CEUS)
- Portale Hypertension
- Aszites
- Hepatozelluläres Karzinom
- Intrahepatischer portosystemischer Shunt