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Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

  • Published:
Journal of Biomedical Science

Abstract

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05–4.17, p = 0.036 and OR 4.95, 95% CI: 1.56–15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (<22) repeats, had an elevated risk than those with longer CAG and GGN (OR 4.32 and 4.57, p = 0.034 and 0.042, respectively). However, neither CAG nor GGN affected the UC risk in non-smokers or heavy smokers (≥25 packs per day-years). AR CAG polymorphism may affect the risk of UC in both genders. In addition, AR polymorphisms may influence carcinogenic effect of medium-dose of cigarette smoking in men.

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Acknowledgements

This study was supported by grants (91GMP012-3 and 91GMP012-4) from the National Science Council, Executive Yuan, Republic of China.

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Authors and Affiliations

  1. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Chin-Hung Liu & Jin-ding Huang

  2. Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

    Jin-ding Huang

  3. Department of Urology, National Taiwan University College of Medicine and Hospital, 7 Chung-Shan South Road, Taipei, 100, Taiwan

    Shi-Wei Huang & Yeong-Shiau Pu

  4. Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

    Tzyh-Chyuan Hour

  5. Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan

    Yung-Kai Huang

  6. School of Public Health, Taipei Medical University, Taipei, Taiwan

    Yu-Mei Hsueh & Hung-Yi Chiou

  7. Institute of Biomedical Sciences Academia Sinica, Taipei, Taiwan

    Te-Chang Lee

  8. Institute of Zoology, Academia Sinica, Taipei, Taiwan

    Kun-Yan Jan

  9. Genomic Research Center, Academia Sinica, Taipei, Taiwan

    Chien-Jen Chen

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  1. Chin-Hung Liu
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Correspondence to Yeong-Shiau Pu.

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Liu, CH., Huang, Jd., Huang, SW. et al. Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. J Biomed Sci 15, 261–269 (2008). https://doi.org/10.1007/s11373-007-9215-x

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  • DOI: https://doi.org/10.1007/s11373-007-9215-x

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