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Tying SUMO modifications to dynamic behaviors of chromosomes during meiotic prophase of Saccharomyces cerevisiae

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Journal of Biomedical Science

Summary

In budding yeast Saccharomyces cerevisiae, centromeres and telomeres are tethered to the nuclear envelope during premeiotic interphase. Immediately after cells enter meiotic prophase, chromosomes undergo global reorganization, including bouquet formation (telomere clustering), non-homologous centromere coupling, homologous pairing, and assembly/disassembly of synaptonemal complexes. These chromosome dynamics have been implicated in promoting pairing, synapsis, crossover DNA recombination and segregation between homologous chromosomes. This review discusses recent studies related to the role of small ubiquitin-like modifier (SUMO) modification in controlling the overall budding yeast chromosome dynamics during meiotic prophase.

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Authors and Affiliations

  1. Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan

    Chun-Hsu Cheng, Feng-Ming Lin, Yu-Hui Lo & Ting-Fang Wang

  2. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 114, Taiwan

    Feng-Ming Lin, Yu-Hui Lo & Ting-Fang Wang

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  1. Chun-Hsu Cheng
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  2. Feng-Ming Lin
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  4. Ting-Fang Wang
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Correspondence to Ting-Fang Wang.

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This article is dedicated to the 20th anniversary of the Institute of Molecular Biology, Academia Sinica. TFW is grateful to all teachers at IMB, including James C. Wang, Ru-Chih Huang, Ping-Chien Huang, Chung Wang, Henry Y. Sun, Jychian Chen, Ming-Zong Lai, Bon-Chu Chung, and Soo-Chen Cheng. We apologize to those whose work could not be cited due to the brevity of this contribution. TFW was supported by the Investigator Award from Academia Sinica and by the Ta-You Wu Award from the National Science Council, Taiwan.

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Cheng, CH., Lin, FM., Lo, YH. et al. Tying SUMO modifications to dynamic behaviors of chromosomes during meiotic prophase of Saccharomyces cerevisiae . J Biomed Sci 14, 481–490 (2007). https://doi.org/10.1007/s11373-007-9176-0

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