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p38 MAPK in regulating cellular responses to ultraviolet radiation

  • Published:
Journal of Biomedical Science

Abstract

Solar ultraviolet (UV) radiation is a major environmental factor that causes DNA damage, inflammation, erythema, sunburn, immunosuppression, photoaging, gene mutations, and skin cancer. p38 mitogen activated protein kinase (MAPK) are strongly activated by UV radiation, and play important roles in regulating cellular responses to UV. In this review, we examine the role played by p38 MAPK in mediating UV-induced cell cycle, apoptosis, inflammation, and skin tanning response. We review the role played by p38 MAPK in transcriptional regulation of key downstream genes that have been implicated in the regulation of cellular responses to UV radiation. Understanding this will undoubtedly help in the prevention and control of UV-induced damage and the development of novel therapeutic strategies.

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Acknowledgements

The work presented here was funded by the National Science Natural foundation of China (No. 30471458) and Science Natural Foundation of Shandong province (No. Y2003c02).

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  1. Medical College, Qingdao University, 422 Room, Boya Building, 308 Ningxia Road, Qingdao, 266071, China

    Li Jinlian, Zhou Yingbin & Wang Chunbo

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  1. Li Jinlian
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  2. Zhou Yingbin
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  3. Wang Chunbo
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Correspondence to Wang Chunbo.

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Jinlian, L., Yingbin, Z. & Chunbo, W. p38 MAPK in regulating cellular responses to ultraviolet radiation. J Biomed Sci 14, 303–312 (2007). https://doi.org/10.1007/s11373-007-9148-4

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  • DOI: https://doi.org/10.1007/s11373-007-9148-4

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