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Association between ADAMTS14_rs4747096 gene polymorphism and bone mineral density of Chinese Han population residing in fluorine exposed areas in ShanXi Province, China

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Abstract

This study aimed to investigate the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The survey was explored in a cross-sectional case–control study conducted in Shanxi, China. The BMD was measured by an ultrasonic bone mineral density instrument. The urine fluoride concentration was detected using the fluoride ion electrode. ADAMTS14_rs4747096 polymorphism was examined by multiplex polymerase chain reaction (PCR) and sequencing. The multinomial logistic regressions found that the urine fluoride was a risk factor for osteopenia (OR = 1.379, 95% CI: 1.127–1.687, P = 0.0018), osteoporosis (OR = 1.480, 95% CI: 1.1138–1.926, P = 0.0035), and rs4747096 AG + GG genotype increased the risk of osteoporosis (OR = 2.017, 95% CI: 1.208–3.369, P = 0.0073). In addition, the interaction between urine fluoride and rs4747096 polymorphism on the risk of decreased BMD also was observed. The study suggests that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for the decrease of BMD. And there is an interaction between the two influencing factors.

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Funding

This work was supported by the National Key R&D Program of China (2022YFC2503000), Natural Science Foundation of China (82273751).

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Authors and Affiliations

  1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Heilongjiang Province, Harbin, 150081, China

    Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang & Yanhui Gao

  2. Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province, Ministry of Health of P. R. China, Harbin Medical University, Heilongjiang Province, Harbin, 150081, China

    Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang & Yanhui Gao

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  1. Ming Qin
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Contributions

Ming Qin: conceptualization, methodology, visualization, and writing–original draft. Yue Gao: writing modification. Meichen Zhang: writing modification. Juahua Wu: resources. Yang Liu: resources. Yuting Jiang: resources. Xiaodi Zhang: investigation. Xin Wang: investigation. Yanmei Yang: writing–review and editing, and supervision. Yanhui Gao: conceptualization, methodology, writing-review and editing, supervision, and project administration.

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Correspondence to Yanhui Gao.

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Qin, M., Gao, Y., Zhang, M. et al. Association between ADAMTS14_rs4747096 gene polymorphism and bone mineral density of Chinese Han population residing in fluorine exposed areas in ShanXi Province, China. Environ Sci Pollut Res 30, 106059–106067 (2023). https://doi.org/10.1007/s11356-023-29698-w

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