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Copper oxychloride–induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage

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Abstract

The current research study investigated the effect of 80 mg/kg b.wt./day curcumin (cur) against 50, 100, and 200 mg/kg copper oxychloride (COC) for 90 days induced testicular damage using histological, ultrastructural, and biochemical techniques. Histological and cellular abnormalities have been noted in seminiferous tubules of COC-treated group and treated group with Cur- and COC-treated group. The biochemical result showed that serum testosterone was significantly decreased in COC-treated rats and Cur COC-treated rats compared with the control groups. Testes copper content and malondialdehyde was increased, whereas the testes total antioxidant, manganese, ferrous, and zinc levels were decreased (p ≥ 0.05) compared to the control groups. In conclusion, the present work reported that the treatment of rats with 80 mg/kg body weight curcumin prior to treatment with COC did not mitigate the deleterious effects of COC and manifested no signs of protection.

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  1. Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

    Heba Nageh Gad El-Hak

  2. Zoology Department, Faculty of Science, Suez University, Suez, Egypt

    Yomn Mohammed Mobarak

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  1. Heba Nageh Gad El-Hak
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Gad El-Hak, H.N., Mobarak, Y.M. Copper oxychloride–induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage. Environ Sci Pollut Res 27, 11649–11662 (2020). https://doi.org/10.1007/s11356-020-07715-6

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