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Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity

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Abstract

Investigation of probable toxic effects of acetamiprid (ACMP) on kidney and comparative analysis of the probable protective effects of vitamin E and melatonin were conducted in the present study. The ethics committee approval was obtained from Inonu University Medical Faculty Ethics Committee. Fifty Balb-c mice were randomly assigned to control, corn oil, ethyl alcohol, ACMP, ACMP + melatonin, ACMP + vitamin E, and ACMP + melatonin + vitamin E groups. At the end of the experiments, rat kidney tissues were incised under anesthesia. Blood samples and kidney tissues were examined. After 21 days of ACMP administration, it was observed that malondialdehyde (MDA), total oxidant status (TOS), BUN, creatinine, IL-6, IL-1β, and TNF-α levels, histopathological damage, and Caspase-3 immunoreactivity scores increased, and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) levels decreased, and histopathological damages were observed. Melatonin and vitamin E administration led to improvements in oxidative stress parameters, renal functions, inflammatory markers, and histopathological findings. ACMP administration led to nephrotoxicity in rat kidney tissues. Although melatonin and vitamin E administrations were effective on ACMP nephrotoxicity separately, co-administration of both was quite effective. Concomitant use of melatonin and vitamin E could be effective on prevention of toxicity.

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Acknowledgments

The authors would like to thank Prof. Dr. Yusuf Turkoz and Prof. Dr. Ahmet Umit Erdemli for their kind assistance. This research did not receive any specific grant from public, commercial, or not-for-profit funding agencies.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Medical Faculty, Inonu University, 44280, Malatya, Turkey

    Mehmet Erman Erdemli & Zeynep Erdemli

  2. Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey

    Emrah Zayman, Mehmet Gul & Semir Gul

  3. Department of Biostatistics, Medical Faculty, Inonu University, Malatya, Turkey

    Harika Gozukara Bag

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  1. Mehmet Erman Erdemli
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  2. Emrah Zayman
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Correspondence to Mehmet Erman Erdemli.

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Erdemli, M.E., Zayman, E., Erdemli, Z. et al. Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity. Environ Sci Pollut Res 27, 9202–9213 (2020). https://doi.org/10.1007/s11356-019-06754-y

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