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A mini review of bisphenol A (BPA) effects on cancer-related cellular signaling pathways

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Abstract

Bisphenol A (BPA) is a plasticizer used widely in many industrial products and is now well established as an endocrine-disrupting chemical (EDC). BPA readily leaches out from these products into the environment and into foodstuffs (from packaging materials) and human exposure can be considerable. Many studies have shown that BPA exposure is associated with a range of chronic human health conditions, including diabetes, cardiovascular disorders, polycystic ovarian disease, hepatotoxicity, and various types of cancer. BPA exerts its effects through deregulating cell signaling pathways associated with cell growth, proliferation, migration, invasion, and apoptosis. Previous studies on the molecular mechanisms of BPA have illustrated a variety of pathways impaired at very low exposure concentrations and that stimulate cellular responses relating to tumorigenesis both in cancer onset and progression. In this mini review, the recent advancements made through in vitro analyses are reported on for the effect of BPA on various cellular signaling pathways focusing on the signaling pathways that play a major role in carcinogenesis.

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Abbreviations

BPA:

bisphenol A

EDCs:

hormone-disrupting compounds

EPA:

environmental protection agency

BW:

body weight

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Acknowledgment

The authors gratefully acknowledge the support from the Research Council of Birjand University of Medical Sciences. The contribution of the Cellular and Molecular Research Center and Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, is also sincerely appreciated.

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Authors and Affiliations

  1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

    Samira Nomiri

  2. Cellular and Molecular Research Center, Clinical Biochemistry Department, Birjand University of Medical Sciences, Birjand, Iran

    Reyhane Hoshyar

  3. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA

    Reyhane Hoshyar

  4. Department of Science and Technology, University of Sannio, via Port’Arsa 11, 82100, Benevento, Italy

    Concetta Ambrosino

  5. IRGS, Biogem, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy

    Concetta Ambrosino

  6. IEOS-CNR, Via Pansini 6, 80131, Naples, Italy

    Concetta Ambrosino

  7. Biosciences, College of Life and Environmental Sciences, University of Exeter, Geoffrey Pope, Stocker Road, Exeter, Devon, EX4 4QD, United Kingdom

    Charles R. Tyler

  8. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran

    Borhan Mansouri

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  1. Samira Nomiri
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  2. Reyhane Hoshyar
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  3. Concetta Ambrosino
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Correspondence to Reyhane Hoshyar or Borhan Mansouri.

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Nomiri, S., Hoshyar, R., Ambrosino, C. et al. A mini review of bisphenol A (BPA) effects on cancer-related cellular signaling pathways. Environ Sci Pollut Res 26, 8459–8467 (2019). https://doi.org/10.1007/s11356-019-04228-9

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  • DOI: https://doi.org/10.1007/s11356-019-04228-9

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