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Bisphenol S exposure affects gene expression related to intestinal glucose absorption and glucose metabolism in mice

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Abstract

Bisphenol S, an industrial chemical, has raised concerns for both human and ecosystem health. Yet, health hazards posed by bisphenol S (BPS) exposure remain poorly studied. Compared to all tissues, the intestine and the liver are among the most affected by environmental endocrine disruptors. The aim of this study was to investigate the molecular effect of BPS on gene expression implicated in the control of glucose metabolism in the intestine (apelin and its receptor APJ, SGLT1, GLUT2) and in the liver (glycogenolysis and/or gluconeogenesis key enzymes (glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK)) and pro-inflammatory cytokine expression (TNF-α and IL-1β)). BPS at 25, 50, and 100 μg/kg was administered to mice in water drink for 10 weeks. In the duodenum, BPS exposure reduces significantly mRNA expression of sodium glucose transporter 1 (SGLT1), glucose transporter 2 (GLUT2), apelin, and APJ mRNA. In the liver, BPS exposure increases the expression of G6Pase and PEPCK, but does not affect pro-inflammatory markers. These data suggest that alteration of apelinergic system and glucose transporters expression could contribute to a disruption of intestinal glucose absorption, and that BPS stimulates glycogenolysis and/or gluconeogenesis in the liver. Collectively, we reveal that BPS heightens the risk of metabolic syndrome.

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Acknowledgements

This work was supported by the Tunisian Ministry of Higher Education and Scientific Research. We are grateful to Institut Français de Tunisie (IFT SSHN2015) for financial support. We thank particularly Dr Jalloul Bouajila from Faculty of Pharmacy of Toulouse (France) for technical assistance.

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Authors and Affiliations

  1. High Institute of Biotechnology of Monastir, Laboratory of Bioresources: Integrative Biology and Valorisation BIOLIVAL, University of Monastir, Monastir 5000, Tunisia

    Raja Rezg

  2. Institut National de la Santé et de la Recherche Médicale (INSERM), U1220, Université Paul Sabatier, UPS, Institut de Recherche en Santé Digestive et Nutrition (IRSD), CHU Purpan, Place du Docteur Baylac, CS 60039, 31024, Toulouse Cedex 3, France

    Anne Abot & Claude Knauf

  3. NeuroMicrobiota, European Associated Laboratory (EAL) INSERM/UCL, Toulouse, France

    Anne Abot & Claude Knauf

  4. Faculty of Sciences of Gabes, Laboratoire de Biodiversité et valorisation des bioressources des zones arides, LR18ES36, University of Gabes, Gabes 6072, Tunisia

    Bessem Mornagui

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  1. Raja Rezg
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  2. Anne Abot
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  3. Bessem Mornagui
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  4. Claude Knauf
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Correspondence to Raja Rezg.

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Animals were treated in the respect of ethic and deontology, and all the procedure was accorded with Guidelines for Ethical Conduct in the Care and Use of Animals.

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The authors declare that there are no conflicts of interest.

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Responsible editor: Philippe Garrigues

Highlights:

• BPS exposure disturbed gene expression of intestinal glucose absorption in male mice.

• BPS exposure impairs hepatic glycogenolysis and/or gluconeogenesis enzymes gene expression.

• Postnatal exposure to bisphenol S at low doses can present a risk factor of metabolic syndrome.

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Rezg, R., Abot, A., Mornagui, B. et al. Bisphenol S exposure affects gene expression related to intestinal glucose absorption and glucose metabolism in mice. Environ Sci Pollut Res 26, 3636–3642 (2019). https://doi.org/10.1007/s11356-018-3823-z

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  • DOI: https://doi.org/10.1007/s11356-018-3823-z

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