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Bifenthrin exerts proatherogenic effects via arterial accumulation of native and oxidized LDL in rats: the beneficial role of vitamin E and selenium

  • Environmental Pollution, Food Contamination, Risk Assessment and Remediation
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Abstract

The purpose of this study was to investigate, for the first time, the effects of Bifenthrin (Bif) chronic exposure on plasmatic and aortic lipid parameters disturbance and their pro-atherogenic possibility in Wistar rats. The ameliorative role of vitamin E (Vit E) and selenium (Se) were also targeted. Thus, rats were treated by gastric gavage with combination of Vit E (100 mg/kg/bw) and Se (0.25 mg/kg/bw) in alone and co-treated groups for 90 days. Apart from control and Vit E-Se groups, all the groups were subjected to Bif (3 mg/kg, via gavage) toxicity. Results showed that Bif increased markedly plasmatic and aortic total cholesterol, LDL-cholesterol, native LDL-apoB-100, and oxidized-LDL, compared to the control. Moreover, Bif treatment significantly increased the plasmatic levels of the pro-inflammatory cytokines TNF-α, IL-2, and IL-6. In addition, the densitometric quantification of protein bands showed that the amount of hepatic native LDL-receptor protein decreased significantly in the intoxicated rats compared to the control group. The expression of arterial LDL receptors (LDLRs) and scavenger receptors (CD36) was amplified owing to Bif toxicity. This harmful effect was confirmed by histological study using Oil-Red-O staining. Owing to their antioxidant capacities, Vit E and Se have maintained all the changes in plasma and aorta lipids and prevented the pro-atherogenic effect observed in Bif-treated animals.

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Acknowledgements

Authors gratefully appreciate the facilities and the support provided by the director and technicians of the Microcirculation Study Laboratory (EA 3509), Faculty of Medicine Lariboisière St-Louis, Paris VII University, Paris. The authors also deeply indebted to Rached Raddadi, Hafedh Trabelsi, and Jihen Jeffel, technicians at Anatomopathol-ogy Laboratory, Gafsa, Tunisia, for their assistance in histological studies.

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Authors and Affiliations

  1. Unité de Biochimie Macromoléculaire et Génétique, Faculté des Sciences de Gafsa, cité Zarroug, Université de Gafsa, 2112, Gafsa, Tunisia

    Anouar Feriani, Lakhdar Ghazouani, Afoua Mufti & Mohamed Ali Borgi

  2. Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia

    Rafik Hachani

  3. Laboratoire d’Etude de la Microcirculation (EA 3509), Faculté de Médecine Lariboisière-St. Louis, Université Paris VII, Paris, France

    Rafik Hachani

  4. Unité de Physiologie et Environnement Aquatique, Faculté des Sciences de Tunis, Université Tunis EL Manar, 2092, Tunis, Tunisia

    Meriam Tir

  5. Laboratoire d’Ecophysiologie Animale, Faculté des Sciences de Sfax, 3018, Sfax, Tunisia

    Mohamed Salah Allagui

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  1. Anouar Feriani
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Correspondence to Anouar Feriani.

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Feriani, A., Hachani, R., Tir, M. et al. Bifenthrin exerts proatherogenic effects via arterial accumulation of native and oxidized LDL in rats: the beneficial role of vitamin E and selenium. Environ Sci Pollut Res 27, 5651–5660 (2020). https://doi.org/10.1007/s11356-018-3771-7

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  • DOI: https://doi.org/10.1007/s11356-018-3771-7

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