Abstract
Meta-analysis with high-quality studies can provide superior evidence. In this paper, we use meta-analysis to analyze the relationship between cadmium (Cd) content in semen and male infertility, and then objectively evaluate the effect of Cd on sperm quality. The objectives of this study were to update our understanding of infertility and to provide evidence to treat and prevent the infertility. We searched potentially relevant studies that were published from establishing database data to April 2018. Articles came from the databases of CNKI, Wanfang, VIP, PubMed, CMCI, and EMBASE. A total of 11 articles were included. We gathered the mean and variance of the infertility group and the control group to compare the Cd content in two groups. In total, the 11 studies include 1707 subjects, 1093 of which were in the infertility group and 614 of which were in the control group. We can get some information from this meta-analysis: SMD = 0.50 (95% Cl 0.39–0.61), Z = 8.92, P < 0.05; the funnel plot of the meta-analysis shows incomplete symmetry, which may have the publication bias. Therefore, the high content of Cd in semen is a causative factor of infertility. The Cd content in semen can be used as an indicator of sperm quality.
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References
Agarwal A, Makker K, Sharma R (2010) Review article: clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 59:2–11. https://doi.org/10.1111/j.1600-0897.2007.00559.x
Bataineh H, Al-Hamood MH, Elbetieha A, Bani HI (1997) Effect of long-term ingestion of chromium compounds on aggression, sex behavior and fertility in adult male rat. Drug Chem Toxicol 20:133–149. https://doi.org/10.3109/01480549709003875
Bulat ZP, Dukic-Cosic D, Dokic M, Bulat P, Matovic V (2009) Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia. Toxicol Ind Health 25:129–135
Chandler J, Hopewell S (2013) Cochrane methods--twenty years experience in developing systematic review methods. Syst Rev 2:76
Chen T et al. (2009) Correlation of trace elements with male infertility. Chin J Health Lab Technol 155–156
Chen M, Li X, Fan R, Yang J, Jin X, Hamid S, Xu S (2018) Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. Chemosphere 194:396–402. https://doi.org/10.1016/j.chemosphere.2017.12.026
Chia SE, Ong CN, Lee ST, Tsakok FHM (1992) Blood concentrations of lead, cadmium, mercury, zinc, and copper and human semen parameters. Arch Androl 29:177–183. https://doi.org/10.3109/01485019208987722
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188. https://doi.org/10.1016/0197-2456(86)90046-2
Desai N, Sharma RK (2009) Physiologic and pathologic levels of reactive oxygen species in neat semen of infertile men. Fertil Steril 92:1626–1631. https://doi.org/10.1016/j.fertnstert.2008.08.109
Du PS, Cabler S, Mcalister DA, Sabanegh E, Agarwal A (2010) The effect of obesity on sperm disorders and male infertility. Nat Rev Urol 7:153–161. https://doi.org/10.1038/nrurol.2010.6
Frühmesser A, Vogt PH, Zimmer J, Witsch-Baumgartner M, Fauth C, Zschocke J, Pinggera GM, Kotzot D (2013) Single nucleotide polymorphism array analysis in men with idiopathic azoospermia or oligoasthenozoospermia syndrome. Fertil Steril 100:81–87. https://doi.org/10.1016/j.fertnstert.2013.03.016
HM V et al (2014) Meta-analysis of data from animal studies: a practical guide. J Neurosci Methods 221:92–102. https://doi.org/10.1016/j.jneumeth.2013.09.010
Ho HY, Wei HJ (2013) The relationship between heavy metal exposure and risk of infertility in Taiwan. Fertil Steril 100:S12–S12. https://doi.org/10.1016/j.fertnstert.2013.07.160
Hovatta O, Venäläinen ER, Kuusimäki L, Heikkilä J, Hirvi T, Reima I (1998) Aluminium, lead and cadmium concentrations in seminal plasma and spermatozoa, and semen quality in Finnish men. Hum Reprod 13:115–119. https://doi.org/10.1093/humrep/13.1.115
Keck C, Bramkamp G, Behre HM, Müller C, Jockenhövel F, Nieschlag E (1995) Lack of correlation between cadmium in seminal plasma and fertility status of nonexposed individuals and two cadmium-exposed patients. Reprod Toxicol 9(35):35–40. https://doi.org/10.1016/0890-6238(94)00053-Y
Keene DJ, Sajad Y, Rakoczy G, Cervellione RM (2012) Testicular volume and semen parameters in patients aged 12 to 17 years with idiopathic varicocele. J Pediatr Surg 47:383–385. https://doi.org/10.1016/j.jpedsurg.2011.11.035
Kefer JC, Agarwal A, Sabanegh E (2010) Role of antioxidants in the treatment of male infertility. Int J Urol 16:449–457. https://doi.org/10.1111/j.1442-2042.2009.02280.x
Kitamura A, Miyauchi N, Hamada H, Hiura H, Chiba H, Okae H, Sato A, John RM, Arima T (2015) Epigenetic alterations in sperm associated with male infertility. Congenit Anom 55:133–144. https://doi.org/10.1111/cga.12113
Laskey JW, Rehnberg GL, Laws SC, Hein JF (1986) Age-related dose response of selected reproductive parameters to acute cadmium chloride exposure in the male long〦vans rat. J Toxicol Environ Health 19:393–401. https://doi.org/10.1080/15287398609530937
Li X, Xing M, Chen M, Zhao J, Fan R, Zhao X, Cao C, Yang J, Zhang Z, Xu S (2017) Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf 139:447–453. https://doi.org/10.1016/j.ecoenv.2017.02.017
Liu J (1986) Studies in technic of cryopreservation for human spermatozoa by liquid nitrogen vapor——I. Effects on sperm survival rate of different methods of storage and different times of cold—balance. doi:https://doi.org/10.13361/j.qdyxy.1986.04.003
Liu J, Qian M, Cai G, Yang J, Zhu Q (2007) Uptake and translocation of Cd in different rice cultivars and the relation with Cd accumulation in rice grain. J Hazard Mater 143:443–447. https://doi.org/10.1016/j.jhazmat.2006.09.057
Lotti F, Maggi M (2018) Sexual dysfunction and male infertility. Nat Rev Urol 15:287–307. https://doi.org/10.1038/nrurol.2018.20
Meerpohl JJ, Timmer A, Antes G (2008) Evidence-based medicine and systematic reviews. Mmw Fortschr Med 150:41–43. https://doi.org/10.1007/BF03365424
Mendiola J, Moreno JM, Roca M, Vergara-Juárez N, Martínez-García MJ, García-Sánchez A, Elvira-Rendueles B, Moreno-Grau S, López-Espín JJ, ten J, Bernabeu R, Torres-Cantero AM (2011) Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study. Environ Health 10:6. https://doi.org/10.1186/1476-069X-10-6
Oguzturk H, Ciftci O, Aydin M, Timurkaan N, Beytur A, Yilmaz F (2012) Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats. Andrologia 44:243–249. https://doi.org/10.1111/j.1439-0272.2012.01273.x
Ponnapakkam TP, Bailey KS, Graves KA, Iszard MB (2003) Assessment of male reproductive system in the CD-1 mice following oral manganese exposure. Reprod Toxicol 17:547–551. https://doi.org/10.1016/S0890-6238(03)00101-1
Pritts EA, Parker WH, Olive DL (2009) Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril 91:1215–1223. https://doi.org/10.1016/j.fertnstert.2008.01.051
Saaranen M, Kantola M, Saarikoski S, Vanha-Perttula T (1989) Human seminal plasma cadmium: comparison with fertility and smoking habits. Andrologia 21:140–145
Saglam HS, Altundag H, Atik YT, Dundar MS, Adsan O (2015) Trace elements levels in the serum, urine, and semen of patients with infertility. Turk J Med Sci 45:443–448
Sakai S, Wakasugi T, Yagi K, Ohnishi A, Ito N, Takeda Y, Yamagishi M (2011) Successful pregnancy and delivery in a patient with adult GH deficiency: role of GH replacement therapy. Endocr J 58:65–68. https://doi.org/10.1507/endocrj.K10E-208
Salort-Llorca C, Mínguez-Serra MP, Silvestre FJ (2008) Drug-induced burning mouth syndrome: a new etiological diagnosis. Med Oral Patol Oral Cir Bucal 13:E167–E170
Semczuk M, Semczuksikora A (2001) New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy. Med Sci Monit 7:332–340
Shaoxian L et al. (1994) Determination of eight elements in semen of infertile patients and normal persons and analysis of zinc to cadmium ratio. J Reprod Med 84–86
Telisman S, Cvitković P, Jurasović J, Pizent A, Gavella M, Rocić B (2000) Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environ Health Perspect 108:45–53. https://doi.org/10.1289/ehp.0010845
Wirth JJ, Mijal RS (2010) Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med 56:147–167. https://doi.org/10.3109/19396360903582216
Wittmaack FM, Shapiro SS (1992) Longitudinal study of semen quality in Wisconsin men over one decade. Wis Med J 91:477
Xiaojia W, Ziming H, Chunli L (1995) Analysis of trace elements zinc, copper, lead and cadmium in human semen. Reprod Contracept 393–395
Xu Z (2012) Detection and analysis of trace elements of seminal plasma in male infertility. Hainan Med J. https://doi.org/10.3969/j.issn.1003-6350.2012.03.039
Yang Y, Liu H, Xiang XH, Liu FY (2013) Outline of occupational chromium poisoning in China. Bull Environ Contam Toxicol 90:742–749. https://doi.org/10.1007/s00128-013-0998-3
Zheng L, Zhu X, Qin J, Ma N, Luo K (2012) Correlation between sperm quality and trace elements in infertile patients international. J Lab Med 33:659–660. https://doi.org/10.3969/j.issn.1673-4130.2012.06.009
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The authors thank Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine.
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This study was supported by the National Natural Science Foundation of China (Grant No. 31472161).
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Zhang, Y., Li, S. & Li, S. Relationship between cadmium content in semen and male infertility: a meta-analysis. Environ Sci Pollut Res 26, 1947–1953 (2019). https://doi.org/10.1007/s11356-018-3748-6
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DOI: https://doi.org/10.1007/s11356-018-3748-6