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Assessment of long-range transport potential of polychlorinated Naphthalenes based on three-dimensional QSAR models

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Abstract

Experimentally determined octanol–air partition coefficients (K OA) for 43 polychlorinated naphthalene (PCN) congeners and experimentally determined subcooled liquid vapor pressures (P L) for 17 PCN congeners were used with comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) to generate three-dimensional quantitative structure–activity relationship (3D–QSAR) models. The data were used to predict K OA values for the other 32 congeners and P L values for the other 58 congeners. The CoMFA and CoMSIA model contour maps showed that the electrostatic fields of the PCN molecules are the most important factors affecting the K OA and P L values. The long-range transport potentials of several PCN homologs were assessed using the following grading system: high mobility (MoCNs), relatively high mobility (DiCNs to TeCNs), relatively low mobility (PeCNs to HeCNs) and low mobility (HeCNs and OCN). The PCN-2 molecule was modified using the contour maps of the two models, and the results showed that introducing an electronegative R1 substituent increased the K OA value but introducing an electropositive R6 substituent decreased the P L value. PCN-2 was in the high mobility class, but introducing these substituents moved the long-range transport potentials of the modified molecules to the relatively high mobility class.

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Authors and Affiliations

  1. The State Key Laboratory of Regional Optimization of Energy System, North China Electric Power University, Beijing, 102206, China

    Xiaolei Wang, Wenen Gu & Yu Li

  2. Appraisal Center for Environment & Engineering, Ministry of Environmental Protection, Beijing, 100012, China

    Ermin Guo

  3. College of Resources and Environmental Sciences, Qingdao Agriculture University, Qingdao, 266109, China

    Chunyue Cui

Authors
  1. Xiaolei Wang
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  2. Wenen Gu
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  3. Ermin Guo
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  4. Chunyue Cui
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  5. Yu Li
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Correspondence to Yu Li.

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Funding

This research was supported by the Fundamental Research Funds for the Central Universities in 2013 (grant no. JB2013146) and the Key Projects in the National Science & Technology Pillar Program in the Eleventh Five-Year Plan Period (grant no. 2008BAC43B01).

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The authors declare that they have no conflict of interest.

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Responsible editor: Marcus Schulz

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Wang, X., Gu, W., Guo, E. et al. Assessment of long-range transport potential of polychlorinated Naphthalenes based on three-dimensional QSAR models. Environ Sci Pollut Res 24, 14802–14818 (2017). https://doi.org/10.1007/s11356-017-8967-8

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  • DOI: https://doi.org/10.1007/s11356-017-8967-8

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