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Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats

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Abstract

The current study presents the bisphenol A exposure and the ameliorative effects of Adiantum capillus-veneris on testicular toxicity induced by bisphenol A. Adult male albino rats were divided into five groups of five animals each: A (control), B (vehicle control), C (toxic), D (protective), and E (ameliorative) were served distilled water, olive oil, bisphenol A (BPA) at 100 mg/kg body weight, A. capillus-veneris plant extract at 25 mg/kg body weight, and BPA + A. capillus-veneris, respectively. All of the doses were administered orally for 15 days, and the rats were then sacrificed. Blood samples for the testosterone assay and both testes were collected for histological examination. The body weight, paired testes weight, relative tissue weight index, Johnsen scoring of tubules, and level of serum testosterone decreased in BPA-treated rats. Similarly, histological examination of the testes in BPA-treated animals revealed a lower number of Leydig cells, an irregular basement membrane, sloughing of germinal layers, vacuolization, a lower number of spermatocytes, and debris in the lumen. However, co-administration of A. capillus-veneris with BPA increased the total antioxidative capacity (330.82 ± 22.46 μmol/mg protein) of the testes and restored the serum testosterone level (1.70 ng/ml); histological features showed restoration in the stages of spermatogenesis. Conclusively, A. capillus-veneris plant extract overcomes the estrogenic effects of BPA on the reproductive system of rats and protects rats’ testes against BPA-induced injury/damage via an antioxidative mechanism that appears to be conciliated.

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Acknowledgments

The authors greatly acknowledged the Higher Education Commission of Pakistan (HEC) for financial support for this study. The World Academy of Science and Chinese Academy of Science are also greatly acknowledged for the CAS-TWAS President fellowship (CAS-TWAS 2014-179). Special thanks are given to the laboratory assistants for their help during experiment and analyses. We would also like to thank Nellie S. and Elizabeth H. for their thoughtful comments and valuable suggestions to improve the language of this manuscript.

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Authors and Affiliations

  1. Chinese Academy of Science (CAS) Key Laboratory of Crust-Mantle Materials and the Environments, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, 230026, People’s Republic of China

    Balal Yousaf, Guijian Liu, Ruwei Wang & Muhammad Ubaid Ali

  2. School of Resource and Environment, Anhui Agriculture University, Hefei, 230026, People’s Republic of China

    Amina

  3. Environmental Toxicology Lab, College of Earth and Environmental Science, University of the Punjab, Lahore, 54590, Pakistan

    Amina, Abdul Qadir, Qudsia Kanwal & Bushra Munir

  4. Developmental Biology Lab, Department of Zoology, University of the Punjab, Lahore, 54590, Pakistan

    Asmatullah

  5. Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, 54590, Pakistan

    Zaigham Abbas

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  10. Zaigham Abbas
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Correspondence to Guijian Liu.

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Yousaf, B., Amina, Liu, G. et al. Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats. Environ Sci Pollut Res 23, 11645–11657 (2016). https://doi.org/10.1007/s11356-016-6330-0

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  • DOI: https://doi.org/10.1007/s11356-016-6330-0

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