Abstract
There is a compelling evidence in support of negative associations between essential trace and toxic elements in different types of cancer. The aim of the present study was to investigate the relationship between carcinogenic (As, Cd, Ni) and anti-carcinogenic (Se, Zn) trace elements in scalp hair samples of different male cancerous patients (esophagus, lung, mouth, and urinary bladder). For comparative purposes, the scalp hair samples of healthy males of the same age group (ranged 35–65 years) as controls were analyzed. Both controls and patients have the same socioeconomic status, localities, dietary habits, and smoking locally made cigarette. The scalp hair samples were oxidized by 65 % nitric acid: 30 % hydrogen peroxide (2:1) ratio in microwave oven followed by atomic absorption spectrometry. The validity and accuracy of the methodology were checked using certified reference material of human hair BCR 397. The mean concentrations of As, Cd, and Ni were found to be significantly higher in scalp hair samples of patients having different cancers as compared to the controls, while reverse results were obtained in the case of Se and Zn levels (p < 0.01). The study revealed that the carcinogenic processes are significantly affecting the trace elements burden and mutual interaction of essential trace and toxic elements in the cancerous patients.
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(2005) Monograph on the pattern of malignant tumor an analysis of ten years data from tumor registry 1992–2001, A publication of Armed Forces Institute of Pathology Rawalpindi. Pakistan
Afridi HI, Kazi TG, Kazi GH et al (2006) Analysis of heavy metals in scalp hair samples of hypertensive patients by conventional and microwave digestion methods. Spect Lett 39:203–214
Afridi HI, Kazi TG, Kazi N et al (2009) Evaluation of arsenic, cobalt, copper and manganese in biological samples of steel mill workers by electrothermal atomic absorption spectrometry. Tox Ind Health 25:59–69
Agency for Toxic Substances and Disease Registry (ATSDR) (1999) Toxicological profile for cadmium. United States Department of Health and Human Services Agency for Toxic Substances and Disease Registry, Atlanta, GA, Report No.: 7440-43-9.
Agency for Toxic Substances and Disease Registry (ATSDR) (2003a) Toxicological profile for nickel. United States Department of Health and Human Services Agency for Toxic Substances and Disease Registry, Atlanta, GA, Report No.: 7440-02-0.
Agency for Toxic Substances and Disease Registry (ATSDR) (2003b) Toxicological profile for arsenic. United States Department of Health and Human Services Agency for Toxic Substances and Disease Registry, Atlanta, GA, Report No.: 7440-38-2
Agency for Toxic Substances, Disease Registry (ATSDR) (2003c) Toxicological profile for zinc. United States Department of Health and Human Services Agency for Toxic Substances and Disease Registry, Atlanta, GA, Report No.:7440-66-6
Ahmed M, Khan AH, and Manzoor A, et. Al (1991) Armed Forces Institute of Pathology, Rawalpindi, JPMA
Alatise OI, Schrauzer GN (2010) Lead exposure: a contributing cause of the current breast cancer epidemic in Nigerian women. Biol Trace Elem Res 136(2):127–139
Arain MB, Kazi TG, Baig JA, Jamali MK, Afridi HI, Jalbani N, Sarfraz RA, Shah AQ, Kandhro GA (2009) Respiratory effects in people exposed to arsenic via the drinking water and tobacco smoking in southern part of Pakistan. Sci Total Environ 407:5524–5530
Arian MB, Kazi TG, Jamali MK, Jalbani N, Afridi HI, Ansari R, Abbas G (2008) Hazardous impact of toxic metals on tobacco leaves grown in contaminated soil by ultrasonic assisted pseudo digestion; Multivariate study. J Hazard Mater 155(1-2):216–224
Barceloux DG (1999) Zinc. J Toxicol, Clin Toxicol 37:279–292
Bates MN, Rey OA, Biggs ML et al (2008) Case–control study of bladder cancer and exposure to arsenic in Argentina. Am J Epidemiol 159:381–389
Beyersmann D (2002) Effects of carcinogenic metals on gene expression. Toxicol Lett 127:63–68
Blot WJ, Devesa SS, McLaughlin JK, Fraumeni JJF (1994) Oral and pharyngeal cancers. Cancer Surv 19–20:23–42
Boik J (1995) Cancer and natural medicine: a textbook of basic science and clinical research. Medical Press, Oregon, p 147
Chang MJ, Walker K, McDaniel RL, Connell CT (2005) Impaction collection and slurry sampling for the determination of arsenic, cadmium, and lead in side stream smoke by inductively coupled plasma-mass spectrometry. J Environ Monit 7:1349–1354
Chen Y, Ahsan H (2004) Cancer burden from arsenic in drinking water in Bangladesh. Am J Public Health 94:741–744
Chen CJ, Chuang YC, Lin TM et al (1985) Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers. Cancer Res 45:5895–5899
Chen CJ, Chuang YC, You SL, Lin HY (1986) A retrospective study on malignant neoplasms of bladder, lung and liver in blackfoot disease endemic area in Taiwan. Br J Cancer 53:399–405
Chen W, Martindale JL, Holbrook NJ, Liu Y (1998) Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol Cell Biol 18:5178–5188
Chen YC, Su HJJ, Guo YL, Hsueh YM, Lee MS, Christiani DC et al (2003) Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med 45:241–248
Chiou HY, Hsueh YM, Liaw KF et al (1995) Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan. Cancer Res 55:1296–1300
Conor R (1998) Selenium: a new entrant into the functional food arena. Trends Food Sci Technol 9:114–118
Costa M (1996) Mehcanisms of nickel genotoxicity and carcinogenicity. In: Chang LW (ed) Toxicology of metals. CRC, Boca Raton, pp pp 245––251
da Silva JJR F, Williams RJP (2001) The biological chemistry of the elements : the inorganic chemistry of life, 2nd edn. Oxford University Press, Oxford, p p. 498
DeWys W, Pories W (1972) Inhibition of a spectrum of animal tumors by dietary zinc deficiency. J Natl Cancer Inst 48:375–381
Diamond WJ, Cowden WL, Goldberg B (1997) An alternative medicine definitive guide to cancer. Future Medicine Publishing, Inc., Tiburon, p 793
Diez M, Arroyo M, Cerdan FJ, Munoz M, Martin MA, Balibrea JL (1989) Serum and tissue trace metal levels in lung cancer. Oncology 46:230–234
Dong LH, Qiang WZ, Rong PY, Shu ZT, Zhu XX, Wang KT (1999) Comparison of serum Zn, Cu and Se contents between healthy people and patients in high, middle and low incidence areas of gastric cancer of Fujian province. World J Gastroenterol 5(1):84–86
El-Bayoumy K (2001) The protective role of selenium on genetic damage and on cancer. Mut Res 475(1–2):123–139
Ferreccio C, Gonzalez PC, Milosavjlevic SV, Marshall GG, Sancha AM, Smith AH (2000) Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology 11:673–679
Franceschi S, Levi F, Vecchia CL, Conti E, Maso LD et al (1999) Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer. Int J Cancer 83:1–4
Goering PL, Waalkes MP, Klaassen CD (1994) Book of Experimental Pharmacology. In: Goyer RA, Cherian MG (eds) Toxicology of metals, biochemical effects, vol 115. Springer, New York, pp 189–214
Grandics P (2003) Cancer: a single disease with a multitude of manifestations. J Carcinog 2:1–9
Gupta SK, Singh SP, Shukla VK (2005) Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder. J Surg Oncol 91:204–208
Gurusamy K, Davidson BR (2007) Trace element concentration in metastatic liver disease: a systematic review. J Trace Elem Med Biol 21:169–177
Hartwig A (2000) Recent advances in metal carcinogenicity. Pure Appl Chem 72:1007–1014
Hartwig A, Schwerdtle T (2002) Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications. Toxicol Lett 127:47–54
Hartwig A, Mullenders LHF, Schlepegrell R, Kasten U, Beyersmann D (1994) Nickel (II) interferes with the incision step in nucleotide excision repair in mammalian cells. Cancer Res 54:4045–4051
Hayes RB (1997) The carcinogenicity of metals in humans. Cancer Causes Control 8:371–385
Hecht SS (1999) Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 91(14):1194–1210
Henshall SM, Afar DE, Rasiah KK, Horvath LG, Gish K, Caras I, Ramakrishnan V, Wong M, Jeffry U, Kench JG et al (2003) Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer. Oncogene 22:6005–6012
Hopenhayn-Rich C, Biggs ML, Fuchs A et al (1996) Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology 7:117–124
Hopenhayn-Rich C, Biggs ML, Smith AH (1998) Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Int J Epidemiol 27:561–569
Hossain K, Akhand AA, Kato M et al (2000) Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J Immunol 165:4290–4297
Hu W, Feng Z, Tang MS (2004) Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis 25:455–462
IARC (International Agency for Research on Cancer) (2004) Tobacco smoke and involuntary smoking, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. IARC, 83 Lyon, pp p. 1005–p. 1178
International Agency for Cancer Research (1993) Monographs on the Evaluation Carcinogenic Risks Human, vol. 58
James MA, Michael DT, Anthony TZ, Jenny RR (2004) Pulmonary responses to welding fumes: role of metal constituents. J Toxicol Environ Health, Part A 67(3):233–249
Jarup L, Bellander T, Hogstedt C, Spang G (1998) Mortality and cancer incidence in Swedish battery workers exposed to cadmium and nickel. Occup Environ Med 55:755–759
Javed AA (2006) Special report: progress of oncology in Pakistan. Indian J Med Paediatr Oncol 27(3):54–59
Karadag F, Cildag O, Altinisik M, Kozaci LD, Kiter G, Altun C (2004) Trace elements as a component of oxidative stress in COPD. Respirology 9:33–37
Kasprzak KS (1995) Possible role of oxidative damage in metal induced carcinogenesis. Cancer Invest 13:411–430
Kasprzak K, Sunderman F, Salnikow K (2003) Nickel carcinogenesis. Mutat Res 533:67–97
Kazi TG, Jalbani N, Arain MB, Jamali MK, Afridi HI, Sarfraz RA, Shah AQ (2009a) Toxic metals distribution in different components of Pakistani and imported cigarettes by electrothermal atomic absorption spectrometer. J Hazard Mater 163(1):302–307
Kazi TG, Jamali MK, Arain MB, Afridi HI, Jalbani N, Sarfraz RA, Ansari R (2009b) Evaluation of an ultrasonic acid digestion procedure for total heavy metals determination in environmental and biological samples. J Hazard Mater 161:1391–1398
Kazi TG, Wadhwa SK, Afridi HI, Kazi N, Kandhro GA, Baig JA, Shah AQ, Kolachi NF, Arain MB (2010) Interaction of cadmium and zinc in biological samples of smokers and chewing tobacco female mouth cancer patients. J Hazard Mater 176:985–991
Kubova J, Hanakova V, Medved J, Stresko V (1997) Determination of lead and cadmium in human hair by atomic absorption spectrometric procedures after solid-phase extraction. Anal Chim Acta 337:329–334
Kuo HW, Chen SF, Wu CC, Chen DR, Lee JH (2002) Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol Trace Elem Res 89:1–11
Lamm SH, Parkinson M, Anderson M et al (1991) Determinants of lung cancer risk among cadmium-exposed workers. AEP 2(3):195–211
Lee YW, Klein CB, Kargacin B et al (1995) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol Cell Biol 15:2547–2557
Leonard A, Gerber GB (1994) Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds. Mutat Res 317:81–88
Letavayova L, Vlckova V, Brozmanova J (2006) Selenium: from cancer prevention to DNA damage. Toxicology 227:1–14
Lewis DR, Southwick JW, Ouellet-Hellstrom R, Rench J, Calderon RJ (1999) Drinking water arsenic in Utah: a cohort mortality study. Environ Health Perspect 107:359–365
Lu H, Shi X, Costa M, Huang C (2005) Carcinogenic effect of nickel compounds. Mol Cell Biochem 279:45–67
Mackay J, Eriksen M. (2002) The tobacco atlas. Geneva: World Health Organization. ISBN 92-4-156209-9, p. 128
McMurray CT, Tainer JA (2003) Cancer, cadmium and genome integrity. Nat Genet 34:239–241
Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108
Paschal DC, Burt V, Caudill SP, Gunter EW, Pirkle JL, Sampson EJ, Miller DT, Jackson RJ (2000) Exposure of the U.S. population aged 6 years and older to cadmium: 1988–1994. Arch Environ Contam Toxicol 38(3):377–383
Pasha Q, Malik SA, Iqbal J, Shah MH (2007) Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors. Biol Trace Elem Res 118:207–216
Pasha Q, Malik SA, Shah MH (2008) Statistical analysis of trace metals in the plasma of cancer patients versus controls. J Hazard Mater 153:1215–1221
Paski SC, Xu Z (2002) Growth factor stimulated cell proliferation is accompanied by an elevated labile intracellular pool of zinc in 3T3 cells. Can J Physiol Pharmacol 80:790–795
Poo JL, Romero RR, Robles JA et al (1997) Diagnostic value of the Cu/Zn ratio in digestive cancer: a case control study. Arch Med Res 28:259–263
Prasad AS (1998) Zinc in human health, an update. J Trace Elem Exp Med 11:63–87
Prasad AS, Beck FW, Endre L, Handschu W, Kukuruga M, Kumar G (1996) Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells. J Lab Clin Med 128:51–60
Rahman M, Vahter M, Sohel N, Yunus M, Abdul Wahed M, Streatfield PK et al (2006) Arsenic exposure and age- and sex-specific risk for skin lesions: a population-based case-referent study in Bangladesh. Environ Health Perspect 114:1847–1852
Raju GJN, Sarita P, Kumar MR et al (2006) Trace elemental correlation study in malignant and normal breast tissue by PIXE technique. Nucl Inst Methods Phys Res B 247(2):361–367
Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241
Rayman MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64:527–542
Sattar N, Scott HR, McMillan DC, Talwar D, Orielly DS, Fell GS (1997) Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls. Nutr Cancer 288:308–312
Savino W, Dardenne M, Velloso LA, Silva-Barbosa SD (2007) The thymus is a common target in malnutrition and infection. Brit J Nutr 98:11–16
Schrauzer GN (2000) Anticarcinogenic effects of selenium. Cell Mol Life Sci 57:1864–1873
Seilkop S, Oller A (2003) Respiratory cancer risks associated with low-level nickel exposure: an integrated assessment based on animal, epidemiological, and mechanistic data. Regul Toxicol Pharmacol 37:173–190
Shankar AH, Prasad AS (1998) Zinc and immune function, the biological basis of altered resistance to infection. Am J Clin Nutr 68:447–463
Shirai T, Iwasaki S, Masui T, Mori T, Kato T, Ito N (1993) Jpn J Cancer Res 84:1023
Siddiqui MKJ, Jyoti SS, Mehrotra PK, Singh K, Sarangi R (2006) Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int 32:630–637
Silvera SAN, Rohan TE (2007) Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 18:7–27
Smith AL, Mario G, Retina H et al (1998) Marked increase in bladder and lung cancer mortality in a region of north Chile due to arsenic in drinking water. Am J Epidemiol 147:660–669
Smith AH, Arroyo AP, Msazumder DNG, Konsnett MJ, Hernandez AL, Beeris M et al (2000) Arsenic-induced skin lesions among Atacamen˜o people in Northern Chile despite good nutrition and centuries of exposure. Environ Health Perspect 108:617–620
Sorahan T, Esmen NA (2004) Lung cancer mortality in UK nickel–cadmium battery workers, 1947–2000. Occup Environ Med 61:108–116
Spallholz JE, Mallory LB, Rhaman MM (2004) Environmental hypothesis: is poor dietary selenium intake an underlying factor for arsenicosis and cancer in Bangladesh and West Bengal, India. Sci Total Environ 323:21–32
Spencer JW, Jacobs JJ (1999) Complementary/alternative medicine: an evidence-based approach. Mosby, Toronto, p 136
Stephanie S, Thomas R (2007) Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Cause Control 18:7–27
Strain J (1994) Putative role of dietary trace element in coronary heart disease and cancer. Br J Biomed Sci 51:241
Sturniolo GC, Di Leo V, Barollo M et al (2000) The many functions of zinc in inflammatory conditions of the gastrointestinal tract. J Trace Elem Exp Med 13:33–39
Takeda A, Goto K, Okada S (1997) Zinc depletion suppresses tumor growth in mice. Biol Trace Elem Res 59:23–29
Tapiero H, Tew KD (2003) Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother 57:399–411
Tsuda T, Babazono A, Yamamoto E et al (1995) Ingested arsenic and internal cancer: a historical cohort study followed for 33 years. Am J Epidemiol 141:198–209
Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, Gao YT et al (2004) Tobacco and cancer: recent epidemiological evidence. J Natl Cancer 96:99–106
Waalkes MP (2000) Cadmium carcinogenesis in review. J Inorg Biochem 79:241–244
Waalkes MP (2003) Cadmium carcinogenesis. Mutat Res/Fundam Mol Mech Mutagen 533(1–2):107–120
Waalkes MP, Kovatch R, Rehm S (1991) Toxicol Appl Pharmacol 108:448
Wadhwa SK, Kazi TG, Afridi HI, Tuzen M, Citak D (2013) Arsenic in water, food and cigarettes: a cancer risk to Pakistani population. J Envirn Sc Health Part A 48:1776–1782
Wagner KA, McDaniel R, Self D (2001) Collection and preparation of side stream cigarette smoke for trace elemental determinations by graphite furnace atomic absorption spectrometry and inductively coupled plasma mass spectrometry. J AOAC Int 84(6):1934–1940
WHO (1996) Trace elements in human nutrition and health. Geneva: World Health Organization
WHO (2002) Reducing risks, promoting healthy life. Geneva: World Health Organization
WHO Regional Office for Europe (2000) Air quality guidelines, 2nd edn. World Health Organization, Copenhagen
Willett WC (2001) Diet and breast cancer. J Int Med 249(5):395–411, 2001
Yaman M (2006) Comprehensive comparison of trace metal concentrations in cancerous and non-cancerous human tissues. Curr Med Chem 13:2513–2525
Yeha C, Houb M, Tsaic S, Lind S, Hsiaod J, Huangd J et al (2005) Superoxide anion radical, lipid peroxides and antioxidant status in the blood of patients with breast cancer. Clin Chim Acta 361:104–111
Zaichick V, Sviridova TV, Zaichick SV (1997) Zinc in the human prostate gland: normal, hyperplastic and cancerous. Int Urol Nephrol 29:565–574
Zowczak M, Iskra M, Paszkowski J, Maflczak M, TorLiflski L, Wysocka EJ (2001) Oxidase activity of ceruloplasmin and concentrations of copper and zinc in serum of cancer patients. Trace Elem Med Biol 15:193–196
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Kazi, T.G., Wadhwa, S.K., Afridi, H.I. et al. Comparison of essential and toxic elements in esophagus, lung, mouth and urinary bladder male cancer patients with related to controls. Environ Sci Pollut Res 22, 7705–7715 (2015). https://doi.org/10.1007/s11356-014-3988-z
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DOI: https://doi.org/10.1007/s11356-014-3988-z