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The fate and risk of selected pharmaceutical and personal care products in wastewater treatment plants and a pilot-scale multistage constructed wetland system

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Abstract

The removal of 12 pharmaceuticals and personal care products (PPCPs) in two full-scale wastewater treatment plants (WWTPs) and a tertiary treatment system was studied. The ecological risks of effluents from both secondary and tertiary treatment systems as well as excess sludge were evaluated. Primary treatment and ultraviolet light disinfection showed limited ability to remove most selected PPCPs. The combination of an anaerobic process and triple-oxidation ditches can eliminate DEET better than the anaerobic/anoxic/oxic process. Adsorption to sludge played a key role in the removal of triclocarban. Multistage constructed wetlands as a tertiary treatment efficiently removed caffeine and ibuprofen from wastewater and could decrease the risk of partial selected PPCPs. Selected PPCPs residues in excess sludge generally produced higher risks to the ecological environment than effluents from WWTPs.

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References

  • Andreozzi R, Cesaro R, Marotta R, Pirozzi F (2006) Evaluation of biodegradation kinetic constants for aromatic compounds by means of aerobic batch experiments. Chemosphere 62(9):1431–1436

    Article  CAS  Google Scholar 

  • Ávila C, Reyes C, Bayona JM, García J (2013) Emerging organic contaminant removal depending on primary treatment and operational strategy in horizontal subsurface flow constructed wetlands: influence of redox. Water Res 47:315–325

    Article  Google Scholar 

  • Babić S, Horvat AJM, Pavlović DM, Kaštelan-Macan M (2007) Determination of pKa values of active pharmaceutical ingredients. TrAC, Trends Anal Chem 26(11):1043–1061

    Article  Google Scholar 

  • Baumgarten B, Jährig J, Reemtsma T, Jekel M (2011) Long term laboratory column experiments to simulate bank filtration: factors controlling removal of sulfamethoxazole. Water Res 45:211–220

    Article  CAS  Google Scholar 

  • Bowman JC, Zhou JL, Readman JW (2002) Sediment–water interactions of natural oestrogens under marine conditions. Mar Chem 77:263–276

    Article  CAS  Google Scholar 

  • Breitholtz M, Näslund M, Stråe D, Borg H, Grabic R, Fick J (2012) An evaluation of free wáter surface wetlands as tertiary sewage water treatment of micro-pollutants. Ecotoxicol Environ Saf 78:63–71

    Article  CAS  Google Scholar 

  • Carballa M, Omil F, Lema JM, Llompart M, Garcia-Jares C, Rodriguez I, Gomez M, Ternes T (2004) Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res 38:2918–2926

    Article  CAS  Google Scholar 

  • Carballa M, Fink G, Omil F, Lema JM, Ternes T (2009) Determination of the solid–water distribution coefficient (Kd) for pharmaceuticals, estrogens and musk fragrances in digested sludge. Water Res 42:287–295

    Article  Google Scholar 

  • Cha J, Cupples AM (2010) Triclocarban and triclosan biodegradation at field concentrations and the resulting leaching potentials in three agricultural soils. Chemosphere 81:494–499

    Article  CAS  Google Scholar 

  • Chen F, Ying GG, Kong LX, Wang L, Zhao JL (2011) Distribution and accumulation of endocrine-disrupting chemicals and pharmaceuticals in wastewater irrigated soils in Hebei, China. Environ Pollut 159:1490–1498

    Article  CAS  Google Scholar 

  • Chen H, Li X, Zhu S (2012) Occurrence and distribution of selected pharmaceuticals and personal care products in aquatic environments: a comparative study of regions in China with different urbanization levels. Environ Sci Pollut R 19:2381–2389

    Article  CAS  Google Scholar 

  • Cirja M, Ivashechkin P, Schäffer A, Corvini PFX (2008) Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR). Rev Environ Sci Biotechnol 7:61–78

    Article  CAS  Google Scholar 

  • Cleuvers M (2003) Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142:185–194

    Article  CAS  Google Scholar 

  • Conkle JL, White JR, Metcalfe CD (2008) Reduction of pharmaceutically active compounds by a lagoon wetland wastewater treatment system in Southeast Louisiana. Chemosphere 73:1741–1748

    Article  CAS  Google Scholar 

  • European Commission (2003) Technical guidance document on risk assessment in support of Commission Directive 93/67/EEC on risk assessment for new notified substances, Commission Regulation (EC) No.1488/94 on risk assessment for existing substances, and Directive 98/8/EC of the European Parliament and of the council concerning the placing of biocidal products on the market. Part I, II and III. EUR 20418 EN/1, 2 and 3. Ispra, Italy: Joint Research Centre

  • Gómez MJ, Martínez Bueno MJ, Lacorte S, Fernández-Alba AR, Agüera A (2007) Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 66:993–1002

    Article  Google Scholar 

  • González MM, Martín J, Santos JL, Aparicio I, Alonso E (2010) Occurrence and risk assessment of nonylphenol and nonylphenol ethoxylates in sewage sludge from different conventional treatment processes. Sci Total Environ 408:563–570

    Article  Google Scholar 

  • Gros M, Petrovi M, Barceló D (2006) Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70(4):678–690

    Article  CAS  Google Scholar 

  • Halling-Sùrensen B (2000) Algal toxicity of antibacterial agents used in intensive farming. Chemosphere 40:731–739

    Article  Google Scholar 

  • Hedgespeth ML, Sapozhnikova Y, Pennington P, Clum A, Fairey A, Wirth E (2012) Pharmaceuticals and personal care products (PPCPs) in treated wastewater discharges into Charleston Harbor, South Carolina. Sci Total Environ 437:1–9

    Article  CAS  Google Scholar 

  • Hijosa-Valsero M, Fink G, Schlüsener MP, Sidrach-Cardona R, Martín-Villacorta J, Ternes T, Bécares E (2011) Removal of antibiotics from urban wastewater by constructed wetland optimization. Chemosphere 83:713–719

    Article  CAS  Google Scholar 

  • Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42:3498–3518

    Article  CAS  Google Scholar 

  • Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 43:363–380

    Article  CAS  Google Scholar 

  • Kim I, Tanaka H (2009) Photodegradation characteristics of PPCPs in water with UV treatment. Environ Int 35:793–802

    Article  CAS  Google Scholar 

  • Leung HW, Minh TB, Murphy MB, Lam JCW, So MK, Martin M, Lam PKS, Richardson BJ (2011) Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China. Environ Int 42:1–9

    Article  Google Scholar 

  • Lin K, Gan J (2011) Sorption and degradation of wastewater-associated non-steroidal anti-inflammatory drugs and antibiotics in soils. Chemosphere 83:240–246

    Article  CAS  Google Scholar 

  • Lin AY, Lin C, Tung H, Chary NS (2010) Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments. J Hazard Mater 183:242–250

    Article  CAS  Google Scholar 

  • Martín J, Camacho-Muñoz D, Santos JL, Aparicio I, Alonso E (2012) Occurrence of pharmaceutical compounds in wastewater and sludge from wastewater treatment plants: removal and ecotoxicological impact of wastewater discharges and sludge disposal. J Hazard Mater 239–240:40–47

    Article  Google Scholar 

  • Matamoros V, García J, Bayona JM (2008) Organic micropollutant removal in a full-scale surface flow constructed wetland fed with secondary effluent. Water Res 42:653–660

    Article  CAS  Google Scholar 

  • Miège C, Choubert JM, Ribeiro L, Eusèbe M, Coquery M (2009) Fate of pharmaceuticals and personal care products in wastewater treatment plants—conception of a database and first results. Environ Pollut 157:1721–1726

    Article  Google Scholar 

  • Moldovan Z (2006) Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. Chemosphere 64:1808–1817

    Article  CAS  Google Scholar 

  • Murata A, Takada H, Mutoh K, Hosoda H, Harada A, Nakada N (2011) Nationwide monitoring of selected antibiotics: distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers. Sci Total Environ 409:5305–5312

    Article  CAS  Google Scholar 

  • Reinhold D, Vishwanathan S, Park JJ, Oh D, Saunders FM (2010) Assessment of plant-driven removal of emerging organic pollutants by duckweed. Chemosphere 80:687–692

    Article  CAS  Google Scholar 

  • Reyes-Contreras C, Hijosa-Valsero M, Sidrach-Cardona R, Bayona JM, Bécares E (2012) Temporal evolution in PPCP removal from urban wastewater by constructed wetlands of different configuration: a medium-term study. Chemosphere 88:161–167

    Article  CAS  Google Scholar 

  • Sabourin L, Beck A, Duenk PW, Kleywegt S, Lapen DR, Li H, Metcalfe CD, Payne M, Topp E (2009) Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. Sci Total Environ 407(16):4596–4604

    Article  CAS  Google Scholar 

  • Santos JL, Aparicio I, Alonso E (2007) Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environ Int 33:596–601

    Article  CAS  Google Scholar 

  • Schaar H, Clara M, Gans O, Kreuzinger N (2010) Micropollutant removal during biological wastewater treatment and a subsequent ozonation step. Environ Pollut 158:1399–1404

    Article  CAS  Google Scholar 

  • Smith GR, Burgett AA (2005) Effects of three organic wastewater contaminants on American toad, Bufo americanus, Tadpoles. Ecotoxicol 14:477–482

    Article  CAS  Google Scholar 

  • Soares A, Guieysse B, Jefferson B, Cartmell E, Lester JN (2008) Nonylphenol in the environment: a critical review on occurrence, fate, toxicity and treatment in wastewaters. Environ Int 34:1033–1049

    Article  CAS  Google Scholar 

  • Spark KM, Swift RS (2002) Effect of soil composition and dissolved organic matter on pesticide sorption. Sci Total Environ 298(1–3):147–161

    Article  CAS  Google Scholar 

  • Stamatelatou K, Frouda C, Fountoulakis MS, Drillia P, Kornaros M, Lyberatos G (2003) Pharmaceuticals and health care products in wastewater effluents: the example of carbamazepine. Water Sci Technol 3:131–137

    CAS  Google Scholar 

  • Stevens-Garmon J, Drewes JE, Khan SJ, McDonald JA, Dickenson ERV (2011) Sorption of emerging trace organic compounds onto wastewater sludge solids. Water Res 45:3417–3426

    Article  CAS  Google Scholar 

  • Stottmeister U, Wießner A, Kuschk P, Kappelmeyer U, Kastner M, Bederski O, Müller RA, Moormann H (2003) Effects of plants and microorganisms in constructed wetlands for wastewater treatment. Biotech Adv 22(1–2):93–117

    Article  CAS  Google Scholar 

  • Suarez S, Lema JM, Omil F (2010) Removal of pharmaceutical and personal care products (PPCPs) under nitrifying and denitrifying conditions. Water Res 44:3214–3224

    Article  CAS  Google Scholar 

  • Sui Q, Huang J, Deng S, Yu G, Fan Q (2010) Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Res 44:417–426

    Article  CAS  Google Scholar 

  • Sui Q, Huang J, Deng S, Chen W, Yu G (2011) Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in different biological wastewater treatment processes. Environ Sci Technol 45:3341–3348

    Article  CAS  Google Scholar 

  • Szabó RK, Megyeri C, Illés E, Gajda-Schrantz K, Mazellier P, Dombi A (2011) Phototransformation of ibuprofen and ketoprofen in aqueous solutions. Chemosphere 84:1658–1663

    Article  Google Scholar 

  • Valentina I, Fabrizio P, Massimo Z (2012) Assessment of ibuprofen tolerance and removal capability in Populus nigra L. by in vitro culture. J Hazard Mater 229:217–223

    Google Scholar 

  • Van Vlaardingen PLA, Posthumus R, Traas TP (2003) Environmental risk limits for alkylphenols and alkylphenol ethoxylates. National Institute of Public Health and the Environment, report 601501019, Bilthoven, The Netherlands

  • Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment—a review. Sci Total Environ 429:123–155

    Article  CAS  Google Scholar 

  • Vymazal J (2009) The use constructed wetlands with horizontal sub-surface flow for various types of wastewater. Ecol Eng 35:1–17

    Article  Google Scholar 

  • Walters E, McClellan K, Halden RU (2010) Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolidsesoil mixtures in outdoor mesocosms. Water Res 44:6011–6020

    Article  CAS  Google Scholar 

  • Westerhoff P, Yoon Y, Snyder S, Wert E (2005) Fate of endocrine-disruptor, pharmaceutical and personal care product chemicals during simulated drinking water treatment processes. Environ Sci Technol 39(17):6649–6663

    Article  CAS  Google Scholar 

  • Wollenberger L, Breitholtz M, Kusk KO, Bengtsson BE (2003) Inhibition of larval development of the marine copepod Acartia tonsa by four synthetic musk substances. Sci Total Environ 305:53–64

    Article  CAS  Google Scholar 

  • Yan C, Yang Y, Zhou J, Liu M, Nie M, Shi H, Gu L (2013) Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment. Environ Pollut 175:22–29

    Article  CAS  Google Scholar 

  • Yang L, Ying G, Su H, Stauber JL, Adams MS, Binet MT (2008) Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata. Environ Toxicol Chem 27:1201–1208

    Article  CAS  Google Scholar 

  • Ying GG, Yu XY, Kookana RS (2007) Biological degradation of triclocarban and triclosan in a soil under aerobic and anaerobic conditions and comparison with environmental fate modelling. Environ Pollut 150:300–305

    Article  CAS  Google Scholar 

  • Ying GG, Kookana RS, Kolpin DW (2009) Occurrence and removal of pharmaceutically active compounds in sewage treatment plants with different technologies. J Environ Monit 11(8):1498–1505

    Article  CAS  Google Scholar 

  • Yu JT, Bouwer EJ, Coelhan M (2006) Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent. Agr Water Manage 86:72–80

    Article  Google Scholar 

  • Zhang DQ, Tan SK, Gersberc RM, Sadreddinia S, Zhu J, Tuan NA (2011) Removal of pharmaceutical compounds in tropical constructed wetlands. Ecol Eng 37:460–464

    Article  Google Scholar 

  • Zhang DQ, Hua T, Gersberg RM, Zhu J, Ng WJ, Tan SK (2012) Fate of caffeine in mesocosms wetland planted with Scirpus validus. Chemosphere 90:1568–1572

    Article  Google Scholar 

  • Zwiener C, Frimmel FH (2003) Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac. Sci Total Environ 309:201–211

    Article  CAS  Google Scholar 

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Acknowledgment

The authors are grateful to the support from Science and Technology Department of Zhejiang Province (2012C23043), Natural Science Foundation of China (nos. 2127712 and 21210008).

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  1. Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China

    Saichang Zhu & Hong Chen

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  1. Saichang Zhu
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  2. Hong Chen
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Correspondence to Hong Chen.

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Responsible editor: Philippe Garrigues

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Zhu, S., Chen, H. The fate and risk of selected pharmaceutical and personal care products in wastewater treatment plants and a pilot-scale multistage constructed wetland system. Environ Sci Pollut Res 21, 1466–1479 (2014). https://doi.org/10.1007/s11356-013-2025-y

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  • DOI: https://doi.org/10.1007/s11356-013-2025-y

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