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Chiral profiling of azole antifungals in municipal wastewater and recipient rivers of the Pearl River Delta, China

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Abstract

Enantiomeric compositions and fractions (EFs) of three chiral imidazole (econazole, ketoconazole, and miconazole) and one chiral triazole (tebuconazole) antifungals were investigated in wastewater, river water, and bed sediment of the Pearl River Delta, South China. The imidazole pharmaceuticals in the untreated wastewater were racemic to weakly nonracemic (EFs of 0.450–0.530) and showed weak enantioselectivity during treatment in the sewage treatment plant. The EFs of the dissolved azole antifungals were usually different from those of the sorbed azoles in the suspended particulate matter, suggesting different behaviors for the enantiomers of the chiral azole antifungals in the dissolved and particulate phases of the wastewater. The azole antifungals were widely present in the rivers. The bed sediment was a sink for the imidazole antifungals. The imidazoles were prevalently racemic, whereas tebuconazole was widely nonracemic in the rivers. Seasonal effects were observed on distribution and chirality of the azole antifungals. Concentrations of the azole antifungals in the river water were relatively higher in winter than in spring and summer while the EF of miconazole in the river water was higher in summer. The mechanism of enantiomeric behavior of the chiral azole antifungals in the environment warrants further research.

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Acknowledgments

This work was financially supported by the National Basic Research Program of China (no. 2009CB421604), NSFC program (nos. 41172319 and 40972221), and the Innovative Program of the CAS (no. KZCX2-EW-108). We thank Mr. He Jiazhuo of the SKLOG for his help in LC-MS/MS. This is contribution from GIGCAS No. 1684.

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Authors and Affiliations

  1. State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China

    Qiuxin Huang, Zhifang Wang, Chunwei Wang & Xianzhi Peng

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Qiuxin Huang, Zhifang Wang, Chunwei Wang & Xianzhi Peng

  3. Environmental Assessment and Monitoring Center, The Fifth Electronics Research Institute of MIIT, Guangzhou, 510610, China

    Qiuxin Huang

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  1. Qiuxin Huang
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  2. Zhifang Wang
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  3. Chunwei Wang
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  4. Xianzhi Peng
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Correspondence to Xianzhi Peng.

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Responsible editor: Leif Kronberg

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Huang, Q., Wang, Z., Wang, C. et al. Chiral profiling of azole antifungals in municipal wastewater and recipient rivers of the Pearl River Delta, China. Environ Sci Pollut Res 20, 8890–8899 (2013). https://doi.org/10.1007/s11356-013-1862-z

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