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Muscular glucose metabolism in middle-age trained rats

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Abstract

Aging decreases the normal organism physiological functions. On the other hand, physical exercise shows health benefits, but little information is known about physical deconditioning at aging. The aim of the present study was to analyze the glucose muscle metabolism in middle-age Wistar rats in response to conditioning and physical deconditioning. The study included three groups: Control (C)—not performed physical training; Trained (T)—performed physical training from 4 to 12 months—swimming exercise for 1 h per day, 5 days per week at 80% of maximal lactate stead state—MLSS; Detrained (D)—performed to physical training from 4 to 8 months and assessed at 12 months (D). Physical training at submaximal intensities induced decreases in body weight (C 588 ± 71, T 515 ± 72, D 576 ± 62 g), and the weight of mesenteric adipose tissue (C 4399 ± 643, T 3007 ± 811, D 4085 ± 540 mg/g), and increases in exercise workload in MLSS intensity (C 4.6 ± 0.4, T 5.8 ± 1.3, D 5.3 ± 0.4% body weight), glucose tolerance (C 12314 ± 1122, T 8428 ± 853, D 9433 ± 1200 mg/dL 120 min), glycogen deposits (C 0.48 ± 0.07, T 0.66 ± 0.18, D 0.46 ± 0.10 mg/100 mg) and glucose uptake by skeletal muscle (C 1.96 ± 0.54, T 3.28 ± 0.53, D 2.55 ± 0.35 μmol/g/h) in trained animals. Additionally, the improvement in exercise load in MLSS, glucose tolerance and glucose uptake was maintained after physical detraining. In summary, the physical training promotes alterations in body weight, fat tissue, aerobic capacity and muscular glucose metabolism in middle-age rats. However, only the aerobic capacity and muscular glucose metabolism were maintained after detraining.

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Abbreviations

VO2max:

Maximum oxygen consumption

MLSS:

Maximum lactate steady state

GLUT:

Glucose transporter

GTT:

Glucose tolerance test

ITT:

Insulin tolerance test

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Acknowledgements

We are grateful to the São Paulo Research Foundation (FAPESP Process No. 2010/12896-0). We thank José Roberto R. Silva for technical assistance. This manuscript was translated for proper English Language by native speaking editors at American Journal Experts.

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Authors and Affiliations

  1. Department of Physical Education, Institute of Biosciences, São Paulo State University (UNESP), AV: 24-A, 1515, Bela Vista, Rio Claro, CEP 13506-900, Brazil

    Ana Carolina Ghezzi, Lucieli Teresa Cambri, José Diego Botezelli & Maria Alice Rostom de Mello

  2. Campinas State University (UNICAMP), Campinas, Brazil

    Ana Carolina Ghezzi & José Diego Botezelli

  3. Department of Physical Education, Federal University of Mato Grosso (UFMT), Cuiabá, Brazil

    Lucieli Teresa Cambri

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  1. Ana Carolina Ghezzi
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  2. Lucieli Teresa Cambri
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Correspondence to Ana Carolina Ghezzi.

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Ghezzi, A.C., Cambri, L.T., Botezelli, J.D. et al. Muscular glucose metabolism in middle-age trained rats. Sport Sci Health 13, 527–533 (2017). https://doi.org/10.1007/s11332-017-0377-2

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