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The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension

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Abstract

Purpose

To assess how expansion sphincter pharyngoplasty (ESP) impacts blood pressure (BP) and health-related quality of life (HRQOL) in hypertensive patients with obstructive sleep apnea (OSA).

Methods

Patients were separated into two groups based upon whether or not they adhered to antihypertensive drug regimens. Patients underwent 24-h ambulatory BP monitoring before and at 6 months post-ESP, while clinical BP measurements and HRQOL questionnaires (SF-36) were conducted over the course of 24 months post-surgery.

Results

We enrolled 62 patients, with 25 and 37 in the medicated and non-medicated groups, respectively. Mean 24-h BP differed significantly, with systolic and diastolic BP (SBP and DBP) decreases of 5.3 mmHg and 2.5 mmHg, respectively (P <0.01). Mean 24-h SBP and DBP decreases in the medicated group were 10.2 mmHg and 4.6 mmHg, respectively (P < 0.001), with significant decreases during the daytime of 8.6 mmHg, 3.0 mmHg, and nighttime of 12.3 mmHg, 7.7 mmHg (P <0.001). In the non-medicated treatment group, 24-h SBP and DBP decreases were 1.9 mmHg and 1.1 mmHg (P < 0.005) with significant decreases in mean nighttime BP values of 3.2 mmHg and 1.9 mmHg (P < 0.001). While pre- and postoperative SF-36 results differed significantly, no differences were observed between the two groups.

Conclusion

ESP decreases BP and improves HRQOL in OSA patients with hypertension, particularly in combination with antihypertensive drugs.

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Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, 230022, Anhui, China

    Dong Wang, Si-Fan Gao, Jun Chen, Hong-Ting Hua, Ye-Hai Liu & Chao-Bing Gao

  2. Sleep Medicine Center, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

    Dong Wang, Yun-Xia Ma, Ye-Hai Liu & Chao-Bing Gao

Authors
  1. Dong Wang
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  2. Si-Fan Gao
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  7. Chao-Bing Gao
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Contributions

Dong Wang: study design, data collection and analysis, and manuscript draft. Si-Fan Gao, Jun Chen, Hong-Ting Hua, and Yun-Xia Ma: data collection and analysis. Ye-Hai Liu: study design and manuscript review. Chao-Bing Gao: study design, manuscript review, and editing.

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Correspondence to Chao-Bing Gao.

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Wang, D., Gao, SF., Chen, J. et al. The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension. Sleep Breath 25, 2155–2162 (2021). https://doi.org/10.1007/s11325-021-02314-2

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  • DOI: https://doi.org/10.1007/s11325-021-02314-2

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