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Sleep disorders and health-related quality of life in patients with interstitial lung disease

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

Interstitial lung diseases (ILD) are chronic and restrictive lung diseases with poor survival and quality of life. The aim of this study was to investigate the frequency of sleep disorders in idiopathic pulmonary fibrosis (IPF) and sarcoidosis and to assess patients’ quality of life in relation to these disorders.

Methods

Forty patients, 19 with IPF, and 21 with sarcoidosis stage II/III were included. They were compared with 15 healthy subjects. All patients performed all-night polysomnography (PSG) and completed the Epworth, Berlin, and Stop-Bang questionnaires. In order to evaluate the quality of life, all patients completed the Short-Form 36 (SF-36) questionnaire.

Results

Of the IPF patients, 68% were diagnosed with mild obstructive sleep apnea (OSA), 5.2% with moderate to severe, 5.2% with severe OSA, and 21% with no OSA. Of patients with sarcoidosis, 52.4% were diagnosed with mild OSA and 4.8% with moderate severity OSA. The remaining 42.8% did not have OSA. The health-related quality of life in both patients with IPF and patients with sarcoidosis was impaired especially in the domains concerning physical health and the level of independence, compared to the control group.

Conclusions

In this sample of patients with IPF and sarcoidosis, obstructive sleep apnea is common at least in a mild degree of severity. The SF-36 questionnaire may be a useful tool for the evaluation of the quality of life in these patients.

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Authors and Affiliations

  1. Pulmonary Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Maria Mavroudi, Despoina Papakosta, Theodore Kontakiotis, Kaliopi Domvri, George Kalamaras, Vasiliki Zarogoulidou, Paschalina Latka & Konstantinos Zarogoulidis

  2. Pulmonary Department, “Theageneio” Anticancer Hospital, Thessaloniki, Greece

    Paul Zarogoulidis

  3. Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, “Hof” Clinics, University of Erlangen, Hof, Germany

    Haidong Huang

  4. Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China

    Wolfgang Hohenforst-Schmidt

Authors
  1. Maria Mavroudi
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  2. Despoina Papakosta
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  3. Theodore Kontakiotis
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  4. Kaliopi Domvri
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  5. George Kalamaras
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  6. Vasiliki Zarogoulidou
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  7. Paul Zarogoulidis
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  8. Paschalina Latka
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  9. Haidong Huang
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  10. Wolfgang Hohenforst-Schmidt
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  11. Konstantinos Zarogoulidis
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Corresponding author

Correspondence to Paul Zarogoulidis.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ιn specific, all the study procedures were approved by the Institutional Review Board of Aristotle University (approval no. 2079) and the Ethics and Bioethics committee (approval no 97).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Mavroudi, M., Papakosta, D., Kontakiotis, T. et al. Sleep disorders and health-related quality of life in patients with interstitial lung disease. Sleep Breath 22, 393–400 (2018). https://doi.org/10.1007/s11325-017-1579-1

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  • DOI: https://doi.org/10.1007/s11325-017-1579-1

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