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Obstructive sleep apnea in a patient with the Melkersson–Rosenthal syndrome

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Abstract

Introduction

Melkersson–Rosenthal syndrome (MRS) is a rare disorder of unknown etiology. It is characterized by the triad of macrocheilitis, peripheral facial palsy, and lingua plicata.

Case report

A 48-year-old nonobese man with a diagnosis of MRS and marked macroglossia was evaluated because of clinically suspected obstructive sleep apnea (OSA). Established causes of OSA such as anatomic abnormalities of the upper airways or the facial skeleton were not present in this patient. Furthermore, hypothyroidism and acromegaly were excluded as underlying diseases. Polysomnography revealed moderate-to-severe OSA. As the swelling of the tongue had been unresponsive to immunosuppressive pharmacotherapy and surgery did not seem to be a reasonable therapeutic option, the patient was finally treated by continuous positive airway pressure therapy.

Discussion

To the best of our knowledge, this is the first report of OSA occurring in a patient with MRS.

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Author information

Authors and Affiliations

  1. University of Giessen Lung Center, Giessen, Germany

    Hans-Joachim Eisele, Frank Reichenberger, Konstantin Mayer, Norbert Weissmann, Werner Seeger & Richard Schulz

  2. University of Giessen Lung Center, Paul-Meimberg-Str. 5, 35392, Giessen, Germany

    Richard Schulz

Authors
  1. Hans-Joachim Eisele
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  2. Frank Reichenberger
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  3. Konstantin Mayer
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  4. Norbert Weissmann
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  5. Werner Seeger
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  6. Richard Schulz
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Corresponding author

Correspondence to Richard Schulz.

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Eisele, HJ., Reichenberger, F., Mayer, K. et al. Obstructive sleep apnea in a patient with the Melkersson–Rosenthal syndrome. Sleep Breath 14, 245–247 (2010). https://doi.org/10.1007/s11325-009-0309-8

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  • DOI: https://doi.org/10.1007/s11325-009-0309-8

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