Abstract
Introduction
Sleep bruxism (SB) is characterized by repetitive and coordinated mandible movements and non-functional teeth contacts during sleep time. Although the etiology of SB is controversial, the literature converges on its multifactorial origin. Occlusal factors, smoking, alcoholism, drug usage, stress, and anxiety have been described as SB trigger factors. Recent studies on this topic discussed the role of neurotransmitters on the development of SB.
Objective
Thus, the purpose of this study was to detect and quantify the urinary levels of catecholamines, specifically of adrenaline, noradrenaline and dopamine, in subjects with SB and in control individuals.
Materials and methods
Urine from individuals with SB (n = 20) and without SB (n = 20) was subjected to liquid chromatography. The catecholamine data were compared by Mann–Whitney’s test (p ≤ 0.05).
Results
Our analysis showed higher levels of catecholamines in subjects with SB (adrenaline = 111.4 µg/24 h; noradrenaline = 261,5 µg/24 h; dopamine = 479.5 µg/24 h) than in control subjects (adrenaline = 35,0 µg/24 h; noradrenaline = 148,7 µg/24 h; dopamine = 201,7 µg/24 h). Statistical differences were found for the three catecholamines tested.
Conclusion
It was concluded that individuals with SB have higher levels of urinary catecholamines.
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References
Lavigne GJ, Kato T, Kolta A, Sessle BJ (2003) Neurobiological mechanisms involved in sleep bruxism. Crit Rev Oral Biol Med 14:30–46
Lavigne GJ, Rompré PH, Poirierl G, Huard H, Katol T, Montplaisir JY (2001) Rhythmic masticatory muscle activity during sleep in humans. J Dent Res 80:443–448
Lobbezoo F, Naeije M (2001) Bruxism is mainly regulated centrally, not peripherally. J Oral Rehabil 28:1085–1091
Amir I, Hermesh H, Gavish A (1997) Bruxism secondary to antipsychotic drug exposure: a positive response to propranolol. Clin Neuropharmacol 20:86–89
Bader G, Lavigne GJ (2000) Sleep bruxism: overview of an oromandibular sleep movement disorder. Sleep Med Rev 4:27–43
Lobbezoo F, Soucy JP, Hartman NG, Montplaisir JY, Lavigne GJ (1997) Effects of the D2 receptor agonist bromocriptine on sleep bruxism: report of two single patient trials. J Dent Res 76:1610–1614
Bostwick JM, Jaffee MS (1999) Buspirone as an antidote to SSRI-induced bruxism in 4 cases. J Clin Psychiatry 60:857–860
Brown ES, Hong SC (1999) Antidepressant-induced bruxism successfully treated with gabapentin. J Am Dent Assoc 130:1467–1469
Micheli F, Pardal MF, Gatto M, Asconapé J, Giannaula R, Parera IC (1993) Bruxism secondary to chronic antidopaminergic drug exposure. Clin Neuropharmacol 16:315
Ohayon MM, Li KK, Guilleminault C (2001) Risk factors for sleep bruxism in the general population. Chest 119:53–61
Patrick R (2004) Selective serotonin reuptake inhibitors (SSRI) and bruxism. Focus Journal for Respir Care Sleep Med Fall:14–21
Stein DJ, Van Greunen G, Niehaus D (1998) Can bruxism respond to serotonin reuptake inhibitors? J Clin Psychiatry 59(3):133
Winocur E, Gavish A, Voikovitch M, Emodi-Perlman A, Eli I (2003) Drugs and bruxism: a critical review. J Orofac Pain 17:99–111
Lobbezoo F, Lavigne GJ, Tanguay R, Montplaisir JY (1997) The effect of catecholamine precursor l-Dopa on sleep bruxism: a controlled clinical trial. Mov Disord 12:73–78
Sjöholm T, Lehtinen I, Piha SJ (1996) The effect of propanolol on sleep bruxism hypothetical considerations based on a case study. Clin Auton Res 6:37–40
Chen WH, Lu YC, Lui CC, Liu JS (2005) A proposed mechanism for diurnal/nocturnal bruxism: hypersensitiviy of presynaptic dopamine receptors in the frontal lobe. J Clin Neurosci 12:161–163
Clark GT, Rugh JD, Handelman SL (1980) Nocturnal masseter muscle activity and urinary catecholamine levels in bruxers. J Dent Res 59:1571–1576
Magee KR (1970) Bruxism related to levodopa therapy. J Am Med Assoc 214:147
Areso MP, Giralt MT, Sainz B, Prieto M, Garcia-Vallejo P, Gomez FM (1999) Occlusal disharmonies modulate central catecholaminergic activity in the rat. J Dent Res 78:1204–1213
Gomez FM, Giralt MT, Sainz B, Arrue A, Prieto M, Garcia-Vallejo P (1999) A possible attenuation of stress-induced increases in striatal dopamine metabolism by the expression of non-functional masticatory activity in the rat. Eur J Oral Sci 107:461–467
Vanderas AP, Menenakou M, Kouimtzis T, Papagiannoulis L (1999) Urinary catecholamine levels and bruxism in children. J Oral Rehabil 26:103–110
Wetter TC, Stiasny K, Winkelmann J, Buhlinger A, Brandenburg U, Penzel T et al (1999) A randomized controlled study of pergolide in patients with restless legs syndrome. Neurology 52:944–950
American Academy of Sleep Medicine (2001) International classification of sleep disorders, revised: diagnostic and coding manual. American Academy of Sleep Medicine, Chicago
Ross GA, Newbould EC, Thomas J, Bouloux PM, Besser GM, Perrett D et al (1993) Plasma and 24 h-urinary catecholamine concentrations in normal and patient populations. Ann Clin Biochem 30:38–44
Osterberg T, Carlsson G (2007) Relationship between symptoms of temporomandibular disorders and dental status, general health and psychosomatic factors in two cohorts of 70-year-old subjects. Gerodontol 24:129–135
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Seraidarian, P., Seraidarian, P.I., das Neves Cavalcanti, B. et al. Urinary levels of catecholamines among individuals with and without sleep bruxism. Sleep Breath 13, 85–88 (2009). https://doi.org/10.1007/s11325-008-0193-7
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DOI: https://doi.org/10.1007/s11325-008-0193-7