Abstract
Purpose
To evaluate whether the extent of restricted diffusion and 2-deoxy-2-[18F] fluoro-d-glucose ([18F]FDG) uptake of pediatric rhabdomyosarcomas (RMS) on positron emission tomography (PET)/magnetic resonance (MR) images provides prognostic information.
Procedure
In a retrospective, IRB-approved study, we evaluated [18F]FDG PET/CT and diffusion-weighted (DW) MR imaging studies of 21 children and adolescents (age 1–20 years) with RMS of the head and neck. [18F]FDG PET and DW MR scans at the time of the initial tumor diagnosis were fused using MIM software. Quantitative measures of the tumor mass with restricted diffusion, [18F]FDG hypermetabolism, or both were dichotomized at the median and tested for significance using Gray’s test. Data were analyzed using a survival analysis and competing risk model with death as the competing risk.
Results
[18F]FDG PET/MR images demonstrated a mismatch between tumor areas with increased [18F]FDG uptake and restricted diffusion. The DWI, PET, and DWI + PET tumor volumes were dichotomized at their median values, 23.7, 16.4, and 9.5 cm3, respectively, and were used to estimate survival. DWI, PET, and DWI + PET overlap tumor volumes above the cutoff values were associated with tumor recurrence, regardless of post therapy COG stage (p = 0.007, p = 0.04, and p = 0.07, respectively).
Conclusion
The extent of restricted diffusion within RMS and overlap of hypermetabolism plus restricted diffusion predict unfavorable clinical outcomes.
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References
Malempati S, Hawkins DS (2012) Rhabdomyosarcoma: review of the Children’s Oncology Group (COG) soft-tissue sarcoma committee experience and rationale for current COG studies. Pediatr Blood Cancer 59:5–10
Ognjanovic S, Linabery AM, Charbonneau B, Ross JA (2009) Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005. Cancer 115:4218–4226
Rodeberg DA, Stoner JA, Hayes-Jordan A, Kao SC, Wolden SL, Qualman SJ, Meyer WH, Hawkins DS (2009) Prognostic significance of tumor response at the end of therapy in group III rhabdomyosarcoma: a report from the children’s oncology group. J Clin Oncol 27:3705–3711
Kleis M, Daldrup-Link H, Matthay K, Goldsby R, Lu Y, Schuster T, Schreck C, Chu PW, Hawkins RA, Franc BL (2009) Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging 36:23–36
Voss SD (2011) Pediatric oncology and the future of oncological imaging. Pediatr Radiol 41(Suppl 1):S172–S185
Lager JJ, Lyden ER, Anderson JR et al (2006) Pooled analysis of phase II window studies in children with contemporary high-risk metastatic rhabdomyosarcoma: a report from the soft tissue sarcoma committee of the children’s oncology group. J Clin Oncol 24:3415–3422
Baum SH, Fruhwald M, Rahbar K, Wessling J, Schober O, Weckesser M (2011) Contribution of PET/CT to prediction of outcome in children and young adults with rhabdomyosarcoma. J Nucl Med 52:1535–1540
Franzius C, Bielack S, Flege S, Sciuk J, Jürgens H, Schober O (2002) Prognostic significance of 18F-FDG and 99mTc-methylene diphosphonate uptake in primary osteosarcoma. J Nucl Med 43:1012–1017
Brenner W, Conrad EU, Eary JF (2004) FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients. Eur J Nucl Med Mol Imaging 31:189–195
Padhani AR, Liu G, Mu-Koh D, Chenevert TL, Thoeny HC, Takahara T, Dzik-Jurasz A, Ross BD, van Cauteren M, Collins D, Hammoud DA, Rustin GJS, Taouli B, Choyke PL (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 11:102–125
Afaq A, Andreou A, Koh D (2010) Diffusion-weighted magnetic resonance imaging for tumour response assessment: why, when and how? Cancer Imaging 10:S179–S188
Oldan JD, Turkington TG, Choudhury K, Chin BB (2015) Quantitative differences in [(18)F] NaF PET/CT: TOF versus non-TOF measurements. Am J Nucl Med Mol Imaging 5:504–514
Ferrari A, Miceli R, Meazza C, Casanova M, Favini F, Morosi C, Trecate G, Marchianò A, Luksch R, Cefalo G, Terenziani M, Spreafico F, Polastri D, Podda M, Catania S, Schiavello E, Giannatempo P, Gandola L, Massimino M, Mariani L (2010) Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma. J Clin Oncol 28:1322–1328
Ries LAG SM, Gurney JG, Linet M, et al. (2005) Cancer incidence and survival among children and adolescents. National Cancer Institute, SEER Program
Wahl RL, Jacene H, Kasamon Y, Lodge MA (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50(Suppl 1):122s–150s
Bakhshi S, Radhakrishnan V, Sharma P, Kumar R, Thulkar S, Vishnubhatla S, Dhawan D, Malhotra A (2012) Pediatric nonlymphoblastic non-Hodgkin lymphoma: baseline, interim, and posttreatment PET/CT versus contrast-enhanced CT for evaluation—a prospective study. Radiology 262:956–968
Riad R, Omar W, Kotb M, Hafez M, Sidhom I, Zamzam M, Zaky I, Abdel-Dayem H (2010) Role of PET/CT in malignant pediatric lymphoma. Eur J Nucl Med Mol Imaging 37:319–329
Bestic JM, Peterson JJ, Bancroft LW (2009) Pediatric FDG PET/CT: physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics 29:1487–1500
Uslu L, Donig J, Link M, Rosenberg J, Quon A, Daldrup-Link HE (2015) Value of 18F-FDG PET and PET/CT for evaluation of pediatric malignancies. J Nucl Med 56:274–286
Kim CK, Gupta NC, Chandramouli B, Alavi A (1994) Standardized uptake values of FDG: body surface area correction is preferable to body weight correction. J Nucl Med 35:164–167
Cuccarini V, Erbetta A, Farinotti M et al (2015) Advanced MRI may complement histological diagnosis of lower grade gliomas and help in predicting survival. J Neuro-Oncol 126:279–288
Schwarzbach MH, Dimitrakopoulou-Strauss A, Willeke F et al (2000) Clinical value of [18F] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas. Ann Surg 231:380–386
Kilic-Eren M, Boylu T, Tabor V (2013) Targeting PI3K/Akt represses hypoxia inducible factor-1α activation and sensitizes rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis. Cancer Cell Int 13:36
Gupta K, Pawaskar A, Basu S, Rajan MGR, Asopa RV, Arora B, Nair N, Banavali S (2011) Potential role of FDG PET imaging in predicting metastatic potential and assessment of therapeutic response to neoadjuvant chemotherapy in Ewing sarcoma family of tumors. Clin Nucl Med 36:973–977
Begent J, Sebire NJ, Levitt G et al (2011) F(18)-Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms' tumour: correlation with conventional imaging, pathology and immunohistochemistry. Eur J Cancer 47:389–396
Kurland BF, Muzi M, Peterson LM, Doot RK, Wangerin KA, Mankoff DA, Linden HM, Kinahan PE (2016) Multicenter clinical trials using 18F-FDG PET to measure early response to oncologic therapy: effects of injection-to-acquisition time variability on required sample size. J Nucl Med 57:226–230
Antonica F, Asabella AN, Ferrari C et al (2014) Useful diagnostic biometabolic data obtained by PET/CT and MR fusion imaging using open source software. Hellenic. J Nucl Med 17(Suppl 1):50–55
Zaidi H, Montandon ML, Alavi A (2010) The clinical role of fusion imaging using PET, CT, and MR imaging. Magn Reson Imaging Clin 18:133–149
Acknowledgments
We thank the members of Daldrup-Link lab for the valuable input and discussions regarding this project.
Funding
This work was supported by a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, grant number R01 HD081123.
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The authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the Institutional Review Board at our institution and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
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Arian Pourmehdi Lahiji and Tatianie Jackson are both co-first authors
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Pourmehdi Lahiji, A., Jackson, T., Nejadnik, H. et al. Association of Tumor [18F]FDG Activity and Diffusion Restriction with Clinical Outcomes of Rhabdomyosarcomas. Mol Imaging Biol 21, 591–598 (2019). https://doi.org/10.1007/s11307-018-1272-1
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DOI: https://doi.org/10.1007/s11307-018-1272-1