Abstract
Purpose
Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction methods.
Procedures
Image quality metrics were measured in various Zr-89 and F-18 PET phantoms, including the NEMA NU 4-2008 image quality phantom. Images were reconstructed using various algorithms.
Results
Zr-89 PET had greater image noise, inferior spatial resolution, and greater spillover than F-18 PET, but comparable recovery coefficients for cylinders of various diameters. Of the reconstruction methods, OSEM3D resulted in the lowest noise, highest recovery coefficients, best spatial resolution, but also the greatest spillover. Scatter correction results were found to be sensitive to varying object sizes.
Conclusions
Zr-89 PET image quality was inferior to that of F-18, and no single reconstruction method was superior in all aspects of image quality.
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Tyler Bradshaw was an intern at AbbVie. Martin Voorbach, David Reuter, Anthony Giamis, Sarah Mudd, and John Beaver are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the publication.
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Bradshaw, T.J., Voorbach, M.J., Reuter, D.R. et al. Image quality of Zr-89 PET imaging in the Siemens microPET Focus 220 preclinical scanner. Mol Imaging Biol 18, 377–385 (2016). https://doi.org/10.1007/s11307-015-0903-z
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DOI: https://doi.org/10.1007/s11307-015-0903-z