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The P2X7 receptor and intracellular pathogens: a continuing struggle

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Abstract

The purinergic receptor, P2X7, has recently emerged as an important component of the innate immune response against microbial infections. Ligation of P2X7 by ATP can stimulate inflammasome activation and secretion of proinflammatory cytokines, but it can also lead directly to killing of intracellular pathogens in infected macrophages and epithelial cells. Thus, while some intracellular pathogens evade host defense responses by modulating with membrane trafficking or cell signaling in the infected cells, the host cells have also developed mechanisms for inhibiting infection. This review will focus on the effects of P2X7 on control of infection by intracellular pathogens, microbial virulence factors that interfere with P2X7 activity, and recent evidence linking polymorphisms in human P2X7 with susceptibility to infection.

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Abbreviations

NDK:

nucleoside diphosphate kinase

NTPase:

nucleoside triphosphatase

PLD:

phospholipase D

ROS:

reactive oxygen species

SNP:

single nucleotide polymorphisms

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Acknowledgments

This work was supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil – CNPq, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro-Programa de Apoio à Núcleos de Excelência -FAPERJ /PRONEX and the University of California.

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  1. Immunobiology Program, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, 21941–902, RJ, Brazil

    Robson Coutinho-Silva & Gladys Corrêa

  2. School of Natural Sciences, University of California, Merced, CA, 95334, USA

    Ali Abdul Sater & David M. Ojcius

  3. Instituto de Biofísica Carlos Chagas Filho – UFRJ, Cidade Universitária, Av. Carlos Chagas Filho no 373, Bloco G do CCS, 21941–902, Ilha do Fundão, Rio de Janeiro, Brazil

    Robson Coutinho-Silva

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Correspondence to Robson Coutinho-Silva.

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Coutinho-Silva, R., Corrêa, G., Sater, A.A. et al. The P2X7 receptor and intracellular pathogens: a continuing struggle. Purinergic Signalling 5, 197–204 (2009). https://doi.org/10.1007/s11302-009-9130-x

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