Abstract
The production of Cephalosporin-C (CPC) a secondary metabolite, using a mold Acremonium chrysogenum was studied in a lab scale Internal loop air lift reactor. Cephalosporin-C production process is a highly aerobic fermentation process. Volumetric gas–liquid mass transfer coefficient (kLa) and viscosity (η) were evaluated, during the growth and production phases of the microbial physiology. An attempt has been made to correlate the broth viscosity, η and volumetric oxygen transfer coefficient, kLa during the Cephalosporin-C production in an air lift reactor. The impact of biomass concentration and mycelial morphology on broth viscosity has been also evaluated. The broth exhibits a typical non-Newtonian fermentation broth. Rheology parameters like consistency index and fluidity index are also studied.
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Mishra, P., Srivastava, P. & Kundu, S. A comparative evaluation of oxygen mass transfer and broth viscosity using Cephalosporin-C production as a case strategy. World J Microbiol Biotechnol 21, 525–530 (2005). https://doi.org/10.1007/s11274-004-3489-1
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DOI: https://doi.org/10.1007/s11274-004-3489-1