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Mechanistic Insights into TiO2 and ZnO Nanoparticle-Induced Metabolic Changes in Escherichia coli Under Solar Simulated Light Irradiation

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Abstract

This study investigated the metabolic response of E. coli after exposure to TiO2 and ZnO NPs under solar simulated irradiation. A total of 14 altered metabolites involved in two metabolic pathways were recognized using multivariate analysis. Polyamine, putrescine was elevated in ZnO-treated group, as an adaptation to oxidative stress in cells, whereas it was significantly reduced in TiO2-treated group. Glycine levels also were elevated in both the treatment groups, showing cellular protection in cells after exposure. In addition, glycine, serine, and threonine metabolism and arginine and proline metabolism were altered in ZnO and TiO2-treated groups respectively.

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Funding

This study was supported by the National Science Foundation-Centers of Research Excellence in Science and Technology (NSF-CREST) program under grant no. HRD-1547754 to Jackson State University.

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Authors and Affiliations

  1. Department of Biology, Jackson State University, Jackson, MS, 39217, USA

    Kavitha Pathakoti & Huey-min Hwang

  2. Interdisciplinary Center for Nanotoxicity, Department of Chemistry, Physics and Atmospheric Sciences, Jackson State University, Jackson, MS, 39217, USA

    Kavitha Pathakoti

  3. Aquatic Ecology Laboratory, Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, 43212, USA

    Manjunath Manubolu

Authors
  1. Kavitha Pathakoti
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  2. Manjunath Manubolu
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  3. Huey-min Hwang
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Correspondence to Kavitha Pathakoti or Huey-min Hwang.

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Pathakoti, K., Manubolu, M. & Hwang, Hm. Mechanistic Insights into TiO2 and ZnO Nanoparticle-Induced Metabolic Changes in Escherichia coli Under Solar Simulated Light Irradiation. Water Air Soil Pollut 231, 16 (2020). https://doi.org/10.1007/s11270-019-4388-2

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