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Interactions of porcine circovirus 2 with its hosts

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Abstract

Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine-producing countries. Since the discovery of this virus, considerable efforts have been devoted to understanding this pathogen and its interactions with its host. Here, we review the current state of knowledge on interactions between host cell factors and PCV2 with respect to viral proliferation, virus-induced cell apoptosis and autophagy, and host antiviral defenses during PCV2 infection. We also review mouse model systems for PCV2 infection.

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Abbreviations

AMPK:

AMP-activated kinase

ASK:

Apoptosis signal-regulating kinase

CycA:

Cyclin A

DC:

Dendritic cell

dpi:

Days post-inoculation

eEF:

Elongation factor

ERK:

Extracellular signal-regulated kinase

hpi:

Hours post-infection

GSH:

Glutathione

HMGCR:

3-Hydroxy-3-methylglutaryl-coenzyme A reductase

Hsp:

Heat shock protein

IFN:

Interferon

IL:

Interleukin

JNK/SAPK:

Jun NH(2)-terminal kinase/stress-activated kinase

MALDI-TOF/TOF:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometer

MAPK:

Mitogen-activated protein kinase

MDA:

Malondialdehyde

miRNA:

MicroRNA

MoDCs:

Monocyte-derived DCs

mTORC:

Mammalian target of rapamycin complex

NFκB:

NF-kappa B

ORF:

Open reading frame

PAM:

Porcine alveolar macrophage

PCV:

Porcine circovirus

PCVD/PCVAD:

Porcine circovirus diseases and porcine circovirus-associated diseases

PDCs:

Plasmacytoid DCs

PI3 K:

Phosphatidylinositol 3-kinase

PK:

Porcine kidney

PMWS:

Post-weaning multisystemic wasting syndrome

pPirh:

Porcine ubiquitin E3 ligase Pirh

RGS:

Regulator of G protein signaling

SOD:

Superoxide dismutase

TLR:

Toll-like receptor

TSC:

Tuberous sclerosis complex

UPS:

Ubiquitin–proteasome system

ZNF:

Zinc finger protein

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Acknowledgments

This work was supported by the Jilin Province Science and Technology Development Projects (Nos. 20140101123JC and 20150204077NY), the Science and Technology Research Program during the Twelfth Five-year Plan Period of Jilin Educational Committee, funded by the National Natural Science Foundation of China (No. 31272385), and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1248).

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Authors and Affiliations

  1. Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi’an Road, Changchun, 130062, Jilin, China

    Linzhu Ren, Xinrong Chen & Hongsheng Ouyang

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  1. Linzhu Ren
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  2. Xinrong Chen
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  3. Hongsheng Ouyang
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Correspondence to Linzhu Ren.

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Ren, L., Chen, X. & Ouyang, H. Interactions of porcine circovirus 2 with its hosts. Virus Genes 52, 437–444 (2016). https://doi.org/10.1007/s11262-016-1326-x

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