Skip to main content

Advertisement

SpringerLink
Log in

Chikungunya emergency in China: microevolution and genetic analysis for a local outbreak

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

A small-scale local chikungunya outbreak occurred in a Guangdong village of southern China in October 2010. The five chikungunya viruses (CHIKV) isolated from the epidemic and three other imported cases obtained from the same period were sequenced and analyzed for phylogenesis. The results demonstrated that all of the eight sequences were clustered in the Eastern, Central, Southern, and African group. However, the local strains and imported isolates showed different sequence variations. A226V in E1 gene and V264A in E2 gene were detected in all three imported isolates, the unique substitutions S250P in E1 gene and H313Y in E2 genes could be observed in four of the five local strains. These significant variations might be some of the causes for the outbreak. It would be an important event for CHIKV to have mutated adaption to the local mosquitoes in China, Aedes albopictus and Aedes aegypti.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. R.N. Charrel, X. Lamballerie, D. Raoult, New Engl. J. Med. 356, 769–771 (2007)

    Article  CAS  PubMed  Google Scholar 

  2. B. McIntosh, P. Jupp, I.D. Santos, S. Afr, J. Sci. 73, 267–269 (1977)

    Google Scholar 

  3. G. Pialoux, B.A. Gauzere, S. Jaureguiberry, M. Strobel, Lancet Infect. Dis. 7, 319–327 (2007)

    Article  PubMed  Google Scholar 

  4. I. Schuffenecker, I. Iteman, A. Michault, S. Murri, L. Frangeul, M.C. Vaney, R. Lavenir, N. Pardigon, J.M. Reynes, F. Pettinelli, L. Biscornet, L. Diancourt, S. Michel, S. Duquerroy, G. Guigon, M.P. Frenkiel, A.C. Bréhin, N. Cubito, P. Desprès, F. Kunst, F.A. Rey, H. Zeller, S. Brisse, PLoS Med. 3, e263 (2006)

    Article  PubMed Central  PubMed  Google Scholar 

  5. M.C. Robinson, T. Roy, Soc. Trop. Med. H. 49, 28–32 (1955)

    Article  CAS  Google Scholar 

  6. S.B. Halstead, J.E. Scanlon, P. Umpaivit, S. Udomsakdi, Am. J. Trop. Med. Hyg. 18, 997–1021 (1969)

    CAS  PubMed  Google Scholar 

  7. A.M. Powers, C.H. Logue, J. Gen. Virol. 88, 2363–2377 (2007)

    Article  CAS  PubMed  Google Scholar 

  8. M. Grandadam, V. Caro, S. Plumet, J.M. Thiberge, Y. Souarès, A.B. Failloux, H.J. Tolou, M. Budelot, D. Cosserat, I. Leparc-Goffart, P. Desprès, Emerg. Infect. Dis. 17, 910–913 (2011)

    Article  PubMed  Google Scholar 

  9. G. Rezza, L. Nicoletti, R. Angelini, R. Romi, A.C. Finarelli, M. Panning, P. Cordioli, C. Fortuna, S. Boros, F. Magurano, Lancet 370, 1840–1846 (2007)

    Article  CAS  PubMed  Google Scholar 

  10. R.S. Lanciotti, O.L. Kosoy, J.J. Laven, A.J. Panella, J.O. Velez, A. Lambert, G.L. Campbell, Emerg. Infect. Dis. 13, 764–767 (2007)

    Article  CAS  PubMed  Google Scholar 

  11. V. Ravi, Indian J. Med. Microbiol. 24, 83–84 (2006)

    Article  CAS  PubMed  Google Scholar 

  12. G. Borgherini, P. Poubeau, F. Staikowsky, M. Lory, N.L. Moullec, J.P. Becquart, C. Wengling, A. Michault, F. Paganin, Clin. Infect. Dis. 44, 1401–1407 (2007)

    Article  PubMed  Google Scholar 

  13. K. Zheng, J. Li, Q. Zhang, M. Liang, C. Li, M. Lin, J. Huang, H. Li, D. Xiang, N.L. Wang, Y. Hong, L. Huang, X.B. Li, D.G. Pan, W. Song, J. Dai, B.X. Guo, D.X. Li, Virol. J. 7, 8 (2008)

    Article  Google Scholar 

  14. G. Xu, H. Dong, N. Shi, S. Liu, A. Zhou, Z.H. Cheng, G.H. Chen, J.Y. Liu, T. Fang, H.W. Zhang, C.Y. Gu, X.J. Tan, J.J. Ye, S.Y. Xie, G.W. Cao, Am. J. Trop. Med. Hyg. 76, 1182–1188 (2007)

    CAS  PubMed  Google Scholar 

  15. D.J. Gubler, G.G. Clark, Emerg. Infect. Dis. 1, 55–57 (1995)

    CAS  PubMed  Google Scholar 

  16. L. Lu, H. Lin, L. Tian, W. Yang, J. Sun, Q. Liu, BMC Public Health 9, 395 (2009)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. S. Santhosh, P. Dash, M. Parida, M. Khan, M. Tiwari, R.P. Lakshmana, Virus Res. 135, 36–41 (2008)

    Article  CAS  PubMed  Google Scholar 

  18. K.A. Tsetsarkin, R. Chen, G. Leal, N. Forrester, S. Higgs, J. Huang, S.C. Weaver, P. Natil, Acad. Sci. USA 108, 7872–7877 (2011)

    Article  CAS  Google Scholar 

  19. J.E. Voss, M.C. Vaney, S. Duquerroy, C. Vonrhein, B.C. Girard, E. Crublet, A. Thompson, G. Bricogne, F.A. Rey, Nature 468, 709–712 (2010)

    Article  CAS  PubMed  Google Scholar 

  20. D. Wu, J. Wu, Q. Zhang, H. Zhong, C. Ke, X. Deng, D. Guan, H. Li, Y.H. Zhang, H.Q. Zhou, J.F. He, L.H. Li, X.F. Yang, Emerg. Infect. Dis. 18, 493–495 (2012)

    Article  PubMed  Google Scholar 

  21. Q. Zhang, J. He, D. Wu, Z. Wang, X. Zhong, H. Zhong, F. Ding, Z. Liu, S. Wang, Z.Y. Huang, Y.H. Zhang, C.W. Ke, D.K. Yuan, W.J. Liang, D.Q. Li, P.H. Chen, PLoS One 17, e42830 (2012)

    Google Scholar 

  22. X.F. Li, T. Jiang, Y.Q. Deng, H. Zhao, X.D. Yu, Q. Ye, H.J. Wang, S.Y. Zhua, F.C. Zhang, E.D. Qin, C.F. Qin, J. Virol. 86, 8904–8905 (2012)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. A.H. Khan, K. Morita, M. Carmen, M. Parquet, F. Hasebe, E.G.M. Mathenge, A. Igarashi, J. Gen. Virol. 83, 3075–3084 (2002)

    CAS  PubMed  Google Scholar 

  24. A.M. Powers, A.C. Brault, R.B. Tesh, S.C. Weaver, J. Gen. Virol. 81, 471–479 (2000)

    CAS  PubMed  Google Scholar 

  25. V.A. Arankalle, S. Shrivastava, S. Cherian, R.S. Gunjikar, A.M. Walimbe, S.M. Jadhav, A.B. Sudeep, A.C. Mishra, J. Gen. Virol. 88, 1967–1976 (2007)

    Article  CAS  PubMed  Google Scholar 

  26. D. Mavalankar, P. Shastri, T. Bandyopadhyay, J. Parmar, K.V. Ramani, Emerg. Infect. Dis. 14, 412–415 (2008)

    Article  PubMed  Google Scholar 

  27. L. Josseran, C. Paquet, A. Zehgnoun, N. Caillere, A.L. Tertre, J.L. Solet, M. Ledrans, Emerg. Infect. Dis. 12, 1994–1995 (2006)

    Article  PubMed  Google Scholar 

  28. X. Lu, X.B. Li, Z.Y. Mo, F.G. Jin, B.L. Wang, H.B. Zhao, X.X. Shan, L. Shi, Am. J. Trop. Med. Hyg. 85, 947–953 (2012)

    Article  Google Scholar 

  29. K.A. Tsetsarkin, C.E. McGee, S.M. Volk, D.L. Vanlandingham, S.C. Weaver, S. Higgs, PLoS One 4, e6835 (2009)

    Article  PubMed Central  PubMed  Google Scholar 

  30. K.A. Tsetsarkin, S.C. Weaver, PLoS Pathog. 7, e1002412 (2011)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. H.C. Hapuarachchi, K.B.A.T. Bandara, S.D.M. Sumanadasa, M.D. Hapugoda, Y.L. Lai, K.S. Lee, L.K. Tan, R.T.P. Lin, L.F.P. Ng, G. Bucht, W. Abeyewickrem, L.C. Ng, J. Gen. Virol. 91, 1067–1076 (2010)

    Article  CAS  PubMed  Google Scholar 

  32. M. Vazeille, S. Moutailler, D. Coudrier, C. Rousseaux, H. Khun, M. Huerre, J. Thiria, J.S. Dehecq, D. Fontenille, Schuffenecker, P. Despres, A.B. Failloux, PLoS One 2, e1168 (2007)

    Article  PubMed Central  PubMed  Google Scholar 

  33. Y.S. Leo, A.L.P. Chow, L.K. Tan, D.C. Lye, L. Lin, L.C. Ng, Emerg. Infect. Dis. 15, 836–837 (2009)

    Article  PubMed  Google Scholar 

  34. E. Gould, P. Gallian, X.D. Lamballerie, R. Charrel, Clin. Microbiol. Infec. 16, 1702–1704 (2010)

    Article  CAS  Google Scholar 

  35. J.E. Brown, E.J. Scholte, M. Dik, W.D. Hartog, J. Beeuwkes, J.R. Powell, Emerg. Infect. Dis. 17, 2335–2337 (2011)

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors sincerely thank Terry Su and Elizabeth Li for their great help with editing the article. This study was supported by the State Key Laboratory of Respiratory Diseases (Grant No. 2007DA780154F0904), The Research Program General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China (Grant No. 2010IK222), The Research Project of Guangdong Entry–Exit Inspection, The Quarantine Bureau (Grant No. 2009GDK11), and Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period (Grant No. 2011ZX09302-003-01), and National Natural Science Foundation of China (Grant No. 31300121).

Author information

Authors and Affiliations

  1. Department of Respiratory, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China

    Xi Lu & Faguang Jin

  2. The State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, 510230, China

    Ziyao Mo, Junfeng Huang & Hongbo Zhao

  3. Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou, 510700, China

    Xiaobo Li & Jicheng Huang

  4. Department of Emergency, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China

    Boliang Wang

  5. College of Light Industry and Food Science, South China University of Technology, Guangzhou, 510640, China

    Lei Shi

Authors
  1. Xi Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaobo Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ziyao Mo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Faguang Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Boliang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Junfeng Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jicheng Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hongbo Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Lei Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ziyao Mo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, X., Li, X., Mo, Z. et al. Chikungunya emergency in China: microevolution and genetic analysis for a local outbreak. Virus Genes 48, 15–22 (2014). https://doi.org/10.1007/s11262-013-0991-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-013-0991-2

Keywords

Search

Navigation